Prognostic value of the oxford classification and the oxford score in IgA nephropathy : a Tunisian study
Joint Authors
Mami, Ikram
Jabali, Halah
Ghabi, Hiba
Bin Kab, Badr
Zawaghi, Muhammad Karim
Hasan, Muhannad
Bin Mahjubah, Hind
Hawwat, Salim
Bin Fatimah, Layla
Bin Hamidah, Fathi
Samawi, Wided
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 31, Issue 6 (31 Dec. 2020), pp.1366-1375, 10 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2020-12-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Abstract EN
Immunoglobulin A nephropathy is the most common primary glomerular disease.
The main challenge in this disease is the evaluation of prognostic factors for end-stage renal disease.
The aim of our study was to describe the characteristics of immunoglobulin A nephropathy, to evaluate the histological data according to Oxford classification, and to identify factors associated with renal survival.
This was a retrospective study, including adults with primary immunoglobulin A nephropathy.
The study was conducted over a period of 10 years.
Renal biopsies were scored according to Oxford classification.
Oxford score, based on the sum of the different histological lesions of Oxford classification, was calculated for each patient.
We included 50 patients with a gender ratio (male:female) of 2.8.
The average age was 35.6 ± 10.6 years.
Fifty-eight percent of the patients had hypertension (HTN).
The median proteinuria was 1.9 g/day.
The median of the glomerular filtration rate was 47.6 mL/min/1.73 m2 .
According to Oxford classification, mesangial proliferation, endocapillary proliferation, glomerulosclerosis, interstitial fibrosis, and/or tubular atrophy and crescents were present in 40%, 38%, 88%, 36%, and 22% of the cases, respectively.
The median Oxford score was 2.
The median follow-up duration was 30 months.
Ten patients (20%) reached end-stage renal disease.
At univariate analysis, HTN, glomerular filtration rate, proteinuria, tubular involvement, and Oxford score >3 were associated with progression to end-stage renal disease (ESRD).
Tubular involvement was an independent risk factor for ESRD.
Our study confirms the prognostic value of the Oxford classification in immunoglobulin A nephropathy.
American Psychological Association (APA)
Jabali, Halah& Ghabi, Hiba& Mami, Ikram& Bin Kab, Badr& Bin Fatimah, Layla& Samawi, Wided…[et al.]. 2020. Prognostic value of the oxford classification and the oxford score in IgA nephropathy : a Tunisian study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 6, pp.1366-1375.
https://search.emarefa.net/detail/BIM-1252675
Modern Language Association (MLA)
Jabali, Halah…[et al.]. Prognostic value of the oxford classification and the oxford score in IgA nephropathy : a Tunisian study. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 6 (Nov. / Dec. 2020), pp.1366-1375.
https://search.emarefa.net/detail/BIM-1252675
American Medical Association (AMA)
Jabali, Halah& Ghabi, Hiba& Mami, Ikram& Bin Kab, Badr& Bin Fatimah, Layla& Samawi, Wided…[et al.]. Prognostic value of the oxford classification and the oxford score in IgA nephropathy : a Tunisian study. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 6, pp.1366-1375.
https://search.emarefa.net/detail/BIM-1252675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1374-1375
Record ID
BIM-1252675