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Thymoquinone improved lead-induced DNA damage and oxidative stress in rat brain
Joint Authors
Mabruk, Ayman
Saqli, Aminah
Manasirah, Fayizah
Izzi, Lubnah
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 69, Issue 2 (30 Apr. 2021), pp.113-118, 6 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2021-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Lead (Pb) is a pervasive industrial and environmental pollutant that seriously impairs the central nervous system, primarily by disrupting the redox balance.
The current research was conducted to explore the possible beneficial action of thymoquinone (TQ), the main active component in Nigella sativa seed volatile oil, against brain oxidative stress and DNA damage caused by Pb.
Wistar adult male rats were treated with TQ (5 mg/kg/day, per os) and/or Pb (2000 ppm of Pb acetate in drinking water) for five weeks.
Results showed that Pb exposure significantly increased metal content, malondialdehyde concentration and DNA damage (assessed by comet assay), but significantly decreased the level of reduced glutathione and the activities of catalase, glutathione peroxidase, and superoxide dismutase in the brain tissue.
These detrimental effects Pb-induced, except tissue metal accumulation, were significantly improved by TQ supplementation.
In conclusion, our findings suggested that TQ might be a promising therapeutic alternative in Pb neurotoxicity.
American Psychological Association (APA)
Mabruk, Ayman& Saqli, Aminah& Manasirah, Fayizah& Izzi, Lubnah. 2021. Thymoquinone improved lead-induced DNA damage and oxidative stress in rat brain. Alexandria Journal of Veterinary Sciences،Vol. 69, no. 2, pp.113-118.
https://search.emarefa.net/detail/BIM-1253394
Modern Language Association (MLA)
Mabruk, Ayman…[et al.]. Thymoquinone improved lead-induced DNA damage and oxidative stress in rat brain. Alexandria Journal of Veterinary Sciences Vol. 69, no. 2 (Apr. 2021), pp.113-118.
https://search.emarefa.net/detail/BIM-1253394
American Medical Association (AMA)
Mabruk, Ayman& Saqli, Aminah& Manasirah, Fayizah& Izzi, Lubnah. Thymoquinone improved lead-induced DNA damage and oxidative stress in rat brain. Alexandria Journal of Veterinary Sciences. 2021. Vol. 69, no. 2, pp.113-118.
https://search.emarefa.net/detail/BIM-1253394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 116-118
Record ID
BIM-1253394