Comparative study on antidiabetic effects of coenzyme q10 and quercetin on streptozotocin-induced hyperglycemia in rats

Abstract EN

As estimated by Federation Diabetes Atlas, the number of diabetic patients will reach globally 592 million in 2035.

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from deficiency of insulin, its resistance or both.

This investigation aimed to explore comparinor the antidiabetic effect of coenzyme Q10 and quercetin on streptozotocin-induced hyperglycemia in rats.

A sum of 24 adult male Albino rats weighing 200±5g each were used and were divided into 4 groups (n= 6 rats).

One group kept as (C -ve) and fed on basal diet all over the experimental period (28 days), while the other groups were intraperitoneal injected with streptozotocin (STZ) at a dose of 40 mg/kg once a week for two weeks.

One of the diabetic groups was fed basal diet only (C +ve) and the other two diabetic groups were fed on Coenzyme Q10 and Quercetin at a dose of 100mg/kg body weight (b.

wt.

) each.

At the end of the trial, rats were mercy sacrificed and the blood and organs were removed then serum glucose, insulin, TSH, LH, TC, TG, HDL, LDL, VLDL, T.

P, Alb.

, T.

B, AST, ALT, ALP, BUN, Creat.

, and uric acid were estimated.

The results revealed that all hyperglycemic rats with orally administered Coenzyme Q10 and Quercetin at a dose of 100mg/kg b.

wt.

each, showed significant increase in BWG, FI, FER and HDL, whereas significant decreases in serum glucose, insulin, TSH, LH, TC, TG, LDL, VLDL, T.

P, Alb.

, T.

B, AST, ALT, ALP, BUN, Creat.

, and uric acid recorded compared to control positive groups.

Furthermore, Coenzyme Q10 induced higher enhancing of improvement rather than quercetin inspite that quercetin has natural healing properties as it is a natural flavonoid.

In conclusion, Coenzyme Q10 and Quercetin have antidiabetic effects on streptozotocin-induced hyperglycemia in rats, indicating higher effect for CoQ10 in spite of singularity for quercetin as a natural flavonoid.