Gene expression of MicroRNA-370 in some Iraqi women with breast cancer
Joint Authors
Mahud, Wafa Sabri
Hasan, Maryam Jasim
Muhammad, Muhammad Jasim
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 2021, Issue (s+conf) (31 Dec. 2021), pp.57-67, 11 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2021-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
Breast cancer becomes a major threat to female health, many reports refer to a high inci-dence of breast cancer in Iraq; especially, in the last years.
The micro RNA-370 molecules have not been reported in Iraqi cancer patients.
Our objective in this study was to identify the expression of micro RNA-370 molecules in breast cancer patients as an early detection bi-omarker of breast tumors and detect its relation with clinicopathological characters of breast cancer patients.
Fifty fresh tissue samples were collected from benign and malignant breast patients in addition to ten normal tissue samples collected as a control group, the age ranged was(19 - 77) years for patients.
The miR-370 gene expression level was measured by the quantitative real-time reaction (qRT-PCR).
Our results demonstrate a high expression of-miR370 in benign and malignant tissues.
The miR‑370 expression level was inversely corre-lated with the age of the patients.
It was a significant relation of miR‑370 gene expression on the left side of breast malignant (p- 0.05).
In conclusion, significantly associated with high miR-370 expression were found depending on age, tumor location, tumor type, and stage of differentiation.
The upregulation of miR-370 gene expression in benign lesions and breast cancer tissue can be applied as a biomarker for early breast cancer Breast cancer becomes a major threat to female health, many reports refer to a high inci-dence of breast cancer in Iraq; especially, in the last years.
The micro RNA-370 molecules have not been reported in Iraqi cancer patients.
Our objective in this study was to identify the expression of micro RNA-370 molecules in breast cancer patients as an early detection bi-omarker of breast tumors and detect its relation with clinicopathological characters of breast cancer patients.
Fifty fresh tissue samples were collected from benign and malignant breast patients in addition to ten normal tissue samples collected as a control group, the age ranged was(19 - 77) years for patients.
The miR-370 gene expression level was measured by the quantitative real-time reaction (qRT-PCR).
Our results demonstrate a high expression of-miR370 in benign and malignant tissues.
The miR‑370 expression level was inversely corre-lated with the age of the patients.
It was a significant relation of miR‑370 gene expression on the left side of breast malignant (p- 0.05).
In conclusion, significantly associated with high miR-370 expression were found depending on age, tumor location, tumor type, and stage of differentiation.
The upregulation of miR-370 gene expression in benign lesions and breast cancer tissue can be applied as a biomarker for early breast cancer detection.
American Psychological Association (APA)
Mahud, Wafa Sabri& Hasan, Maryam Jasim& Muhammad, Muhammad Jasim. 2021. Gene expression of MicroRNA-370 in some Iraqi women with breast cancer. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 2021, no. (s+conf), pp.57-67.
https://search.emarefa.net/detail/BIM-1255671
Modern Language Association (MLA)
Mahud, Wafa Sabri…[et al.]. Gene expression of MicroRNA-370 in some Iraqi women with breast cancer. Ibn al-Haitham Journal for Pure and Applied Science Special issue conference (2021), pp.57-67.
https://search.emarefa.net/detail/BIM-1255671
American Medical Association (AMA)
Mahud, Wafa Sabri& Hasan, Maryam Jasim& Muhammad, Muhammad Jasim. Gene expression of MicroRNA-370 in some Iraqi women with breast cancer. Ibn al-Haitham Journal for Pure and Applied Science. 2021. Vol. 2021, no. (s+conf), pp.57-67.
https://search.emarefa.net/detail/BIM-1255671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 65-67
Record ID
BIM-1255671