Histopathological alterations of male and female reproductive systems induced by alloxan in rats

Abstract EN

The objective of this study is to determine the histological effects experimentally induced by injection of alloxan 100 mg/kg B.

w.

on the histopathological structure of reproductive organs of male and female albino rats.

The results showed that treatment with alloxan cause alteration in testis include irregular shape and size of seminiferous tubules, irregular division of spermatid cells, degeneration and necrosis of Sertoli cells and paucity of sperms in the lumen of tubules.

While histological examination of epididymis showed the lumen of it free from sperms, thickening of muscular layer and interstitial tissue between the epididymis canal.

The histological alteration of female reproductive organs includes disturbances in development of primary follicles of ovaries, hemorrhage in the interstitial tissue as well as atrophy in the uterine glands with hyperplasia of the epithelial cells of uterus.

The conclusion of this study showed that alloxan cause histological alteration in reproductive organs of male and female rats.