Potential protective effect of ginseng on dexamethasone-induced liver damage via motivation of anti-apoptotic and antioxidant activities in rats \
Joint Authors
Lubdah, Muhammad Ali Muhammad
Taha, Nabil M.
al-Kharashi, Wafa E.
Hashim, Amal S.
Mandour, Abd al-Wahhab A.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 68, Issue 1 (31 Jan. 2021), pp.31-39, 9 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2021-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
-The current study aimed to explore the protective roles of ginseng against dexamethasone liver devastating effects.
Sixty male rats were equally allocated into six groups; G1: control, G2: ginseng aqueous extract (200 mg/kg B.W.
orally /4 weeks), G3: dexamethasone (1mg/kg B.W.
i.p/one week then decapitated), G4: dexamethasone- withdrawal group (1mg/kg B.W.
i.p/one week and decapitated at the end of experiment), G5: dexamethasone ginseng treated group (injected with dexamethasone/one week then treated with ginseng/other 3weeks), and G6: ginseng-dexamethasone-ginseng group (received ginseng/two weeks followed by dexamethasone/one week then ginseng/another week).
Dexamethasone significantly increased serum liver enzymatic activities alongside with mild to moderate hepatic vacuolation, and periportal mononuclear infiltration suggesting liver damage.
The level of hepatic malondialdehyde (MDA) was elevated markedly with subsequent decline in the reduced glutathione concentration following challenged with dexamethasone.
Moreover, the hepatic expression of thioredoxin mRNA transcript was down-regulated while BCL2-associated X protein (Bax) mRNA transcript was up-regulated providing imbalance in antioxidant and apoptosis pathway.
Ginseng treatment ameliorated the damaged effects of dexamethasone on the liver as indicated by attenuation of elevated liver enzymatic activities, augmentation the reduced glutathione level, up-regulation thioredoxin mRNA transcription along with down-regulation of Bax mRNA expression in liver tissue.
Conclusively, ginseng exerted a protective action on dexamethasone hepatic side effects through anti-apoptotic and antioxidant properties.
American Psychological Association (APA)
al-Kharashi, Wafa E.& Lubdah, Muhammad Ali Muhammad& Mandour, Abd al-Wahhab A.& Taha, Nabil M.& Hashim, Amal S.. 2021. Potential protective effect of ginseng on dexamethasone-induced liver damage via motivation of anti-apoptotic and antioxidant activities in rats \. Alexandria Journal of Veterinary Sciences،Vol. 68, no. 1, pp.31-39.
https://search.emarefa.net/detail/BIM-1257438
Modern Language Association (MLA)
al-Kharashi, Wafa E.…[et al.]. Potential protective effect of ginseng on dexamethasone-induced liver damage via motivation of anti-apoptotic and antioxidant activities in rats \. Alexandria Journal of Veterinary Sciences Vol. 68, no. 1 (Jan. 2021), pp.31-39.
https://search.emarefa.net/detail/BIM-1257438
American Medical Association (AMA)
al-Kharashi, Wafa E.& Lubdah, Muhammad Ali Muhammad& Mandour, Abd al-Wahhab A.& Taha, Nabil M.& Hashim, Amal S.. Potential protective effect of ginseng on dexamethasone-induced liver damage via motivation of anti-apoptotic and antioxidant activities in rats \. Alexandria Journal of Veterinary Sciences. 2021. Vol. 68, no. 1, pp.31-39.
https://search.emarefa.net/detail/BIM-1257438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 38-39
Record ID
BIM-1257438