تقدير فعالية بعض المتغيرات الكيموحيوية كمضادات الأكسدة في مشائم النساء الحوامل المصابة بداء المقوسات

Abstract EN

Reregulation of biochemical profile of host as a result of host cells-pathogen interaction may involve in pathogenesis of toxoplasmosis disease.

The biochemical parameters in the placenta of Toxoplasma-infected pregnant women and non-infected pregnant women (control group) were investigated The criteria taken into consideration are: Superoxide dismutase (SOD), Peroxidase (Px), Glutathione- S- transferase (GST), Lactate dehydrogenase (LDH), Aryl esterase (AE), Acetylcholine esterase (AchE), Vitamin A, C and E As well as placental electrolytes including: Sodium (Na+), Potassium (K+), Chloride (Cl-), Calcium (Ca++), Selenium (Se), Cupper (Cu), Zinc (Zn), Iron (Fe), Magnesium (Mg) and Manganese (Mn).

The results showed: a non-significant increase in the activity of SOD, GST, LDH and AchE during 6-9 months, and activity of AE during 1-3 months, were determined whereas the activity of Px was decreased in all periods of pregnancyA non- significant increase in the level of vitamin E and non-significant decrease in levels of vitamin A and C during pregnancy periods in placentae of infected pregnant Were observed.

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A significant increase (p≤0.01) in levels of Na+ and K+ during 1-3 months and Ca++ during 3-6 months, whereas the level of Cl- decreased during pregnancy periods.

A significant increase (p≤0.01) in levels of Seand Mg during 6-9 months and a non- significant increase in level of Cu during 1-3 months and 6-9 months, whereas the level of Zn, Fe and Mn significantly decreased in all periods of Pregnancy in placenta infected women.