Histopathological changes induced by monosodium glutamate and sodium nitrite in the development of eye in albino mice mus musculus
Other Title(s)
التغيرات المرضية النسجية المحدثة بكلوتامات احادي الصوديوم و نتريت الصوديوم في تطور العين للفئران المهق Mus musculus
Joint Authors
al-Dhannun, Sanabil Abd al-Munim
Abd, Ali Ishkur
Source
التربية و العلم : مجلة علمية للبحوث العلمية الأساسية
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2021-09-30
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Arabic Abstract
تناولت الدراسة الحالية تاثير إحدى المضافات الغذائية و هي كلوتامات احادي الصوديوم MSG، واحدى المواد الحافظة وهي نتريت الصوديوم NaNO2 على التطور الجنيني لعين الفئران المهق في اليوم الرابع عشر و الثامن عشر من الحمل و التاثيرات المرضية النسجية التي تلحقها هذه المواد.
بينت نتائج الدراسة من خلال الفحص المجهري وجود تغيرات مرضية لعين الأجنة، فقد أظهرت العين في اليوم 14 للحمل و عند المعاملة بMSG 9غم / كغم ازدواجية الشبكية و هي من أهم الأضرار التي ظهرت في هذه المرحلة و هي نتيجة ملفتة للنظر ومهمة.
أما عند المعاملة بNaNO2 110ملغم / كغم لوحظ عدم انتظام في العدسة، تشوه القرنية فرط تنسج في النسيج العصبي للشبكية وعند المعاملة بتداخل كال المادتين لوحظ نخر في نسيج القرنية والياف العدسة و في الطبقة الضفيرية الداخلية للشبكية.
اما في اليوم 18 للحمل و عند المعاملة بMSG 9 هي ازدواجية الشاملة والملفتة للنظر أيضا غم / كغم فقد كانت أهم األض ارر أيضا الشبكية فضالً عن نخر العصب البصري.
أما عند المعاملة بNaNO2 110ملغم / كغم شوهد تفكك في سداة القرنية وتفكك في الخاليا المستقبلة للضوء وفي حالة تداخلهما ظهر نخر واختزال واسع في كل طبقات الشبكية.
و استنتجت الدراسة ان استهلاك هذه المواد اكثر من المسموح يؤدي الى حدوث افات نسجية في العين.
English Abstract
The present study aimed to discover the histopathological of the Monosodium glutamate (MSG), and Sodium nitrite (NaNO2), on the embryonic development of the eyes of albino mice Mus musculus.
On the fourteenth and eighteenth day of pregnancy, the stage of organogenesis in these animals.
A concentration of 9 g/kg of MSG, a concentration of 110 mg/kg of NaNO2, and the interaction between them used.
The results of the study showed the presence of pathological changes to the eyes of the fetuses.
The eye on the 14th day of pregnancy, when 9 g/kg of MSG used, there were retinal duplication, increased vascularization in the retina, condensation of some nuclei of the inner nuclear layer and ganglion cells, and necrosis in the vicinity of the lens.
When treating with NaNO2 110 mg/kg, there was an irregularity in the lens, corneal distortion, hyperplasia of the retinal nerve tissue.
When the two materials overlapped, the corneal tissue necrosis, the lens fiber, and the inner plexiform layer were observed.
On the 18th day of pregnancy, when treated with MSG 9g/kg, the most significant overall and striking damage was retinal duplication and optic nerve necrosis.
When treated with NaNO2 110 mg/kg, the corneal stroma and dissociation were seen in the photoreceptor cells.
In the case of their overlapping, extensive necrosis and reduction appeared in all layers of the retina.
The study concluded that consuming MSG and NaNO2 more than the permissible limit during pregnancy leads to tissue lesions harmful to the eye.
The present study aimed to discover the histopathological of the Monosodium glutamate (MSG), and Sodium nitrite (NaNO2), on the embryonic development of the eyes of albino mice Mus musculus.
On the fourteenth and eighteenth day of pregnancy, the stage of organogenesis in these animals.
A concentration of 9 g/kg of MSG, a concentration of 110 mg/kg of NaNO2, and the interaction between them used.
The results of the study showed the presence of pathological changes to the eyes of the fetuses.
The eye on the 14th day of pregnancy, when 9 g/kg of MSG used, there were retinal duplication, increased vascularization in the retina, condensation of some nuclei of the inner nuclear layer and ganglion cells, and necrosis in the vicinity of the lens.
When treating with NaNO2 110 mg/kg, there was an irregularity in the lens, corneal distortion, hyperplasia of the retinal nerve tissue.
When the two materials overlapped, the corneal tissue necrosis, the lens fiber, and the inner plexiform layer were observed.
On the 18th day of pregnancy, when treated with MSG 9g/kg, the most significant overall and striking damage was retinal duplication and optic nerve necrosis.
When treated with NaNO2 110 mg/kg, the corneal stroma and dissociation were seen in the photoreceptor cells.
In the case of their overlapping, extensive necrosis and reduction appeared in all layers of the retina.
The study concluded that consuming MSG and NaNO2 more than the permissible limit during pregnancy leads to tissue lesions harmful to the eye.
Data Type
Conference Papers
Record ID
BIM-1266033
American Psychological Association (APA)
al-Dhannun, Sanabil Abd al-Munim& Abd, Ali Ishkur. 2021-09-30. Histopathological changes induced by monosodium glutamate and sodium nitrite in the development of eye in albino mice mus musculus. بحوث علوم الحياة عطاء مستمر رغم جائحة كورونا (3 : 2021 : جامعة الموصل، العراق). . Vol. 30, no. 3 (Special issue conference) (2021), pp.1-12.الموصل، العراق : جامعة الموصل، كلية التربية للعلوم الصرفة،.
https://search.emarefa.net/detail/BIM-1266033
Modern Language Association (MLA)
al-Dhannun, Sanabil Abd al-Munim& Abd, Ali Ishkur. Histopathological changes induced by monosodium glutamate and sodium nitrite in the development of eye in albino mice mus musculus. . الموصل، العراق : جامعة الموصل، كلية التربية للعلوم الصرفة،. 2021-09-30.
https://search.emarefa.net/detail/BIM-1266033
American Medical Association (AMA)
al-Dhannun, Sanabil Abd al-Munim& Abd, Ali Ishkur. Histopathological changes induced by monosodium glutamate and sodium nitrite in the development of eye in albino mice mus musculus. . بحوث علوم الحياة عطاء مستمر رغم جائحة كورونا (3 : 2021 : جامعة الموصل، العراق).
https://search.emarefa.net/detail/BIM-1266033
