Developing new microemulsions containing high molecular weight heparin sodium for transdermal application

Other Title(s)

تطوير مستحلبات دقيقة تحوي هيبارين الصوديوم ذي الوزن الجزيئي المرتفع بغرض التطبيق الجلدي

Dissertant

Yusuf, Yusuf Ali

Thesis advisor

al-Karad, Jamal al-Yusuf

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2020

English Abstract

Heparin is an anticoagulant which administrated usually either by Intravenous or Subcutaneous injection.

This study aimed to formulate microemulsions containing heparin using nonionic surfactants for transdermal application.

Five microemulsions were developed and characterized for their rheological properties and droplets size.

The in vitro permeation of heparin was measured using Franz diffusion cell.

Hence, an HPLC-method was developed to study the permeability through the skin.

Furthermore the efficacy of one developed heparin was orally and transdermally tested using rats model in comparison to subcutaneous administration.

The rheograms and droplets size measurements evidenced that the developed drug delivery systems are microemulsions.

Furthermore, the permeation of heparin using MEs could be proved using Franz diffusion cells.

Moreover, the in vivo results could reflect the effect of absorbed heparin through the skin as well as after oral administration.

Finally the novel MEs containing heparin can be promised carriers for noninvasive application of heparin.

Main Subjects

Pharmacology

Topics

No. of Pages

53

Table of Contents

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Materials, instruments and methods.

Chapter Three : Results.

Chapter Four : Discussion.

Chapter Five : Conclusion.

References.

American Psychological Association (APA)

Yusuf, Yusuf Ali. (2020). Developing new microemulsions containing high molecular weight heparin sodium for transdermal application. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1269027

Modern Language Association (MLA)

Yusuf, Yusuf Ali. Developing new microemulsions containing high molecular weight heparin sodium for transdermal application. (Master's theses Theses and Dissertations Master). Isra University. (2020).
https://search.emarefa.net/detail/BIM-1269027

American Medical Association (AMA)

Yusuf, Yusuf Ali. (2020). Developing new microemulsions containing high molecular weight heparin sodium for transdermal application. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1269027

Language

English

Data Type

Arab Theses

Record ID

BIM-1269027