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Attenuation of cardiovascular responses to laryngoscopy and tracheal intubation with verapamil
Joint Authors
Amireh, Amir M.
al-Khalayilah, Khalid K.
Abu Sini, Ali Muhammad
al-Kilani, Muhammad
Jabir, Ibrahim
Source
Journal of the Royal Medical Services
Issue
Vol. 10, Issue 1 (30 Jun. 2003), pp.49-52, 4 p.
Publisher
The Royal Medical Services Jordan Armed Forces
Publication Date
2003-06-30
Country of Publication
Jordan
No. of Pages
4
Main Subjects
Topics
Abstract EN
Objective: To evaluate the efficacy of verapamil in controlling hemodynamic responses to tracheal intubation under general anesthesia. Methods: We studied eighty normotensive patients (American Society of Anesthesiologists physical status (I)) undergoing elective surgery.
They were randomly assigned to two main groups.
Group I included 20 patients randomly allocated into two equal subgroups (1a and 1b).
Group II were divided into three subgroups with 20 patients each (IIc, IId and IIe) to receive saline (control), verapamil 0.05milligrams/kilogram body weight, verapamil 0.1 milligrams /kilogram body weight.
Patients with anticipated difficult tracheal intubation, hypertension, renal or hepatic diseases were excluded.
The drugs were administered 60 seconds before commencing laryngoscopy.
Anesthesia was induced with thiopentone 5 milligrams/kilogram body weight intravenously and fentanyl 2mc?g/kg intravenously, vecuronium 0.15 milligrams/kilogram body weight.
During anesthesia, ventilation was assisted or controlled with 1% halothane and 50% nitrous oxide in oxygen.
Laryngoscopy lasting 30sec.
was attempted 2 minutes after administration of thiopentone and vecuronium. Results: Patients receiving saline exhibited significant increase in systolic, diastolic arterial pressures, mean arterial pressure, and heart rate associated with tracheal intubation. The increases in mean arterial pressure and heart rate were attenuated in patients treated with verapamil.
These findings suggest that bolus injection of verapamil was an effective method of controlling hypertension and tachycardia associated with intubation. Conclusion: This technique may be useful in hypertensive patients and it may protect them from serious complications.
Further studies in hypertensive patients might be helpful.
American Psychological Association (APA)
Jabir, Ibrahim& al-Kilani, Muhammad& al-Khalayilah, Khalid K.& Abu Sini, Ali Muhammad& Amireh, Amir M.. 2003. Attenuation of cardiovascular responses to laryngoscopy and tracheal intubation with verapamil. Journal of the Royal Medical Services،Vol. 10, no. 1, pp.49-52.
https://search.emarefa.net/detail/BIM-127383
Modern Language Association (MLA)
al-Khalayilah, Khalid K.…[et al.]. Attenuation of cardiovascular responses to laryngoscopy and tracheal intubation with verapamil. Journal of the Royal Medical Services Vol. 10, no. 1 (Jun. 2003), pp.49-52.
https://search.emarefa.net/detail/BIM-127383
American Medical Association (AMA)
Jabir, Ibrahim& al-Kilani, Muhammad& al-Khalayilah, Khalid K.& Abu Sini, Ali Muhammad& Amireh, Amir M.. Attenuation of cardiovascular responses to laryngoscopy and tracheal intubation with verapamil. Journal of the Royal Medical Services. 2003. Vol. 10, no. 1, pp.49-52.
https://search.emarefa.net/detail/BIM-127383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 52
Record ID
BIM-127383