أثر إعطاء النابروكسين Naproxen و السيليكوكسيب Celecoxib في الألم التالي للمعالجة اللبية المنجزة بجلسة واحدة

Abstract EN

Aim: The aim of this study was to evaluate the efficacy of celecoxib compared to naproxen in the management of post-endodontic pain in single-canal anterior and premolar teeth with irreversible pulpitis.

Methods: Sixty single-canal anterior and premolar teeth with irreversible pulpitis were included in this study.

Patients were randomly allocated into three groups according to the administered medicament: naproxen group (n=20), celecoxib group (n=20), and placebo group (n=20).

Naproxen group received naproxen 500 mg tablets, celecoxib group received celecoxib 100 mg capsules, and placebo group received placebo (starch containing capsules).

All patients were given one tablet/capsule at the following time intervals: 1 hour preoperatively, 12, 24, 36, 48, hours postoperatively.

A single operator performed a single-visit endodontic treatment for all patients.

Visual analogue scale (VAS) was used to record pain at 6, 12, 24, 48 hours and 1 week after obturation.

Data were statistically analyzed using Kruskal-Wallis and Mann-Whitney U tests.

The significance level was set at p<0.05.

Results: There were no statistically significant differences in VAS pain values between the studied groups 6, 12, 48 hours, and 1 week after obturation (p>0.05).

At 24 hours after obturation, there were no statistically significant differences between naproxen and celecoxib groups (p>0.05).

However, there were statistically significant differences between placebo group and both naproxen and celecoxib groups at that time (p<0.05).

Conclusions: Naproxen and celecoxib were found to be effective in reducing post-endodontic pain in single-canal anterior and premolar teeth with irreversible pulpitis.

The effectiveness of naproxen was similar to celecoxib.