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Description of rare genetic variants discovered with Promega PowerPlex® forensic amplification kits during STR analysis of routine paternity and kinship cases
Other Title(s)
وصف المتغيرات الجينية النادرة التي تم اكتشافها باستخدام مجموعات تكثير الحمض النووي الجنائي من Promega PowerPlex® أثناء تحليل التكرارات المترادفة القصيرة STR لحالات الأبوة و القرابة الروتينية
Joint Authors
Salih, Khalifah M.
Hasan, Dhurgham H.
al-Nuaymah, Amirah J.
Mahmud, Hanan K.
Salman, Nadiyah F.
Sabah, Majid A.
Source
Arab Journal of Forensic Sciences and Forensic Medicine
Issue
Vol. 2, Issue 2 (31 Dec. 2020), pp.111-117, 7 p.
Publisher
Naif Arab University for Security Sciences Arab Society for Forensic Sciences and Forensic Medicine
Publication Date
2020-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Short Tandem Repeats (STR) have been widely used to create a discriminating DNA profile during the forensic investigation of a crime.
The Paternity and Kinship Division at Medico-legal Directorate (MLD)/ Baghdad, provides a DNA fingerprinting service for paternity and kinship requests from different courts of law and police departments from across the country.
Several rare variants were observed during DNA analysis such as rare off-ladder alleles, tri-allelic pattern as well as allele dropout.
Variants that have been transmitted among family members were investigated in this study.
During the period between 2008 to 2019, 38309 samples have been analyzed in the Paternity and Kinship Laboratories for DNA profiling to resolve the referred cases.
DNA profiles found to have unusual STR patterns (off-ladder, tri-allelic pattern, inter-loci variable were analyzed and documented).
A total of 17 variants were observed which were as shared among family members.
Rare off-ladder alleles (9 cases + inter-loci variant 2 cases), as well as 6 cases of tri-allelic patterns were recorded.
The presence of each type of these variants among family members proves that these variations are of genetic origin.
They also represent rare genetic variants specific to the Iraqi populations that could be used for the establishment of a new Iraqi DNA database, which might be useful for genealogical studies as well as in terms of resolving familial, social, and moral disputes.
American Psychological Association (APA)
Mahmud, Hanan K.& Salman, Nadiyah F.& Hasan, Dhurgham H.& Salih, Khalifah M.& Sabah, Majid A.& al-Nuaymah, Amirah J.. 2020. Description of rare genetic variants discovered with Promega PowerPlex® forensic amplification kits during STR analysis of routine paternity and kinship cases. Arab Journal of Forensic Sciences and Forensic Medicine،Vol. 2, no. 2, pp.111-117.
https://search.emarefa.net/detail/BIM-1276894
Modern Language Association (MLA)
Mahmud, Hanan K.…[et al.]. Description of rare genetic variants discovered with Promega PowerPlex® forensic amplification kits during STR analysis of routine paternity and kinship cases. Arab Journal of Forensic Sciences and Forensic Medicine Vol. 2, no. 2 (2020), pp.111-117.
https://search.emarefa.net/detail/BIM-1276894
American Medical Association (AMA)
Mahmud, Hanan K.& Salman, Nadiyah F.& Hasan, Dhurgham H.& Salih, Khalifah M.& Sabah, Majid A.& al-Nuaymah, Amirah J.. Description of rare genetic variants discovered with Promega PowerPlex® forensic amplification kits during STR analysis of routine paternity and kinship cases. Arab Journal of Forensic Sciences and Forensic Medicine. 2020. Vol. 2, no. 2, pp.111-117.
https://search.emarefa.net/detail/BIM-1276894
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1276894