Effects of valproic acid drug on hepatic tissues in female mice
Other Title(s)
تأثيرات عقار حامض الفالبروبك على الأنسجة الكبدية في إناث الفئران
Joint Authors
Qusaybat, Tariq Abd Allah Mustafa
al-Naqaz, al-Naji Umar Masud
al-Tarshani, Um al-Izz Abd al-Jalil
al-Siraj, Khalidah Rashid
al-Tarhuni, Amal Ibrahim
Source
Journal of Pure and Applied Sciences
Issue
Vol. 19, Issue 2 (30 Jun. 2020), pp.127-134, 8 p.
Publisher
Publication Date
2020-06-30
Country of Publication
Libya
No. of Pages
8
Main Subjects
Abstract EN
Valproic acid is one of many prescribed drugs that used to control seizures in people with epilepsy and may cause degrees of hepatic toxicity.
This study intended to research the histological changes that may happen in liver in relationship with delayed organization and overdose treatment of valproic acid.
35 female albino mice were used, they were divided into four groups, group (I) included 5 animals and served as control group, group (II) included 10 animals and received gradually doses of valproic acid for ten weeks , starting with (15mg/kg/day) as minimum recommended dose and ending with (60mg/kg/day) as maximum recommended dose, group (III) included 10 animals and received overdose (120mg/kg/day) for one week, group (IV) included 10 animals and treated exactly as group (II) then the animals were left for recovery for three weeks.
The animals were sacrificed at the end of each period and the liver was extracted.
The valproic acid incited numerous histological changes in liver included inflammatory cells, necrosis, hydropic degenerations, angiectasis, accumulation of kupffer cells and pigments, cytological changes and fibers deposition.
It can be concluded that valproic acid causes variable degrees of hepatic injuries and the impact was time related.
Incomplete recovery was recorded after stopping the drug administration.
American Psychological Association (APA)
al-Naqaz, al-Naji Umar Masud& Qusaybat, Tariq Abd Allah Mustafa& al-Tarshani, Um al-Izz Abd al-Jalil& al-Siraj, Khalidah Rashid& al-Tarhuni, Amal Ibrahim. 2020. Effects of valproic acid drug on hepatic tissues in female mice. Journal of Pure and Applied Sciences،Vol. 19, no. 2, pp.127-134.
https://search.emarefa.net/detail/BIM-1285004
Modern Language Association (MLA)
al-Naqaz, al-Naji Umar Masud…[et al.]. Effects of valproic acid drug on hepatic tissues in female mice. Journal of Pure and Applied Sciences Vol. 19, no. 2 (2020), pp.127-134.
https://search.emarefa.net/detail/BIM-1285004
American Medical Association (AMA)
al-Naqaz, al-Naji Umar Masud& Qusaybat, Tariq Abd Allah Mustafa& al-Tarshani, Um al-Izz Abd al-Jalil& al-Siraj, Khalidah Rashid& al-Tarhuni, Amal Ibrahim. Effects of valproic acid drug on hepatic tissues in female mice. Journal of Pure and Applied Sciences. 2020. Vol. 19, no. 2, pp.127-134.
https://search.emarefa.net/detail/BIM-1285004
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1285004