تأثير داء السكري على مستوى الدهون في حوامل إناث الجرذ الأبيض

Abstract EN

Seventy two (72) white female rats, were used and were randomly divided into three groups (eachgroup containing (24) animals), the first group (n=8) a control and represented by the T1 were drawingblood from two days before pregnancy and 16 female injected into the sixth day of pregnancywith a solution of salt Physiological intraperitoneal, 8 females were withdrawn blood from day (18)of pregnancy and 8 females leave for the birth, the second group T2 was developed diabetes beforethe month of pregnancy injected into Alloxan and a concentration of( 150) mg / kg of body weightintraperitoneal and divided into (8) females was drawing blood from two days before the pregnancyand (8) females were drawing blood from day (18) of pregnancy and (8) females leave for the birth, and the third group T3 divided into (8) females were drawing blood from two days before pregnancyand (16) female were developed diabetes by injected into the 6 day of pregnancy Alloxan and a concentrationof (150) mg / kg of body weight intraperitoneal, (8) were withdrawn blood from day 18of gestation and (8) females leave for the birth1 Weight of mothers are calculated during pregnancyon (9, 18) and calculate the number of births and weights at birth also collected blood samples in theperiod before conception and day (18) of the study of the following criteria: measuring the concentrationof total cholesterol in the blood (TC), Triglyceride (TG), High density lipoproteins (HDL-C), Low density lipoproteins (LDL-C) and very low density lipoproteins (VLDL-C).

The results showedthat the induced diabetes in rats before pregnancy T2, during pregnancy T3 led to a significant high(P <0.05) in the concentration of TC, TG, LDL, VLDL and also significant decrease (P <0.05) in theconcentration of HDL in serum compared with control T11 Concluded from current study that thediabetes-induced effect on lipid profile in the pregnant female white rat.