Study the effect of fat substitutes on weight gain in rats consuming high fat diets

Abstract EN

In the present study, the effect of fat substitutes on weight gain in rats consuming high fat diets was investigated.

Biological evaluation, organs weight, lipid profile, blood glucose and histopathological structure of rat's liver fed on high fat diet, were determined.

Thirty adult female albino rats, weighting (115±5g), rats were divided into five groups which fed on high fat diet and 10% fatsubstitutes (palm oil, dextrin, whey protein and cellulose).

Results showed that feeding rats on 10% Palm oil showed non-significant changes, while10% cellulose significantly decreased BWG as compared to negative control group.

For lipid fractionsand blood glucose, the best result showed in rats fed on basal diet with 10% cellulose.

Histopathological examination of liver showed less or more normalized in the groups fed on fat substitutes.

Thus, the study demonstrated that fat substitutes possesses the ability of weight reduction and decreased the bad effect high fat diet in rats.