Potential effect of peach, red grape fruits and their mixture as powder on hypercholestrolestrolemic rats

Abstract EN

This study was conducted to investigate the effect of different levels (2.5% and 5% ) of peach (Prunus persica)and red grape(Vitis vinfera, L.

) fruitsas powder on hypercholesterolemia male albino rats.

Forty male albino rats, weighing between (140±10g B.

Wt), ) were divided into 8 equal group, one was kept as a control (-ve) was fed on basal diet and, while, the other 7 groups were induced hypercholesterolemia by Triton-x-100 (100mg/kg of the weight of the rat) one of them kept as control (+ve) was feed on basal diet only without any addition, and another groups fed basal diet additionally the powder of investigated fruits for 28 days.

Determined the biological parameters as ( BWG, FER, and FI), total cholesterol, triglycerides, lipoprotein fraction (HDL-c, LDL-c, VLDL-c, AI), glucose, kidney functions (urea, uric acid and creatinine), liver functions (ALT and AST), have been determined.

The obtained results indicated that peach, red grape fruits and their mixture contains enhancement of phenolic compounds, its use as antioxidant.

Data also of peach, red grape fruits and their mixture showed significant enhancement in weight gain, food intake, food efficiency ratio, albumin level, TC, TG, HDL-c, LDL-c, VLDL-c, and all other parameters including internal organs weights.

In conclusion: peach, red grape and mixture of them could be considered powerful nutraceutical therapeutic means for the treatment of hypercholesterolemia rats.