The potential effects of garden cress seeds (lepidium sativum l.)‎ on the bone of female rats suffering from osteoporosis

Abstract EN

This study was designed to investigate the probable effect of Garden Cress seeds (GCs) on the bone of osteoporotic female rats.

Thirty healthy adult female albino rats (weigh, 200±10g) were used in this study.

The rats were haphazardly divided into two main groups.

The first main group (6 rats) was fed on a basal diet as a control negative group.

The second main group (24 rats) fed on a basal diet containing 100mg prednisone acetate as a source of glucocorticoid/kg diet for two weeks to induce osteoporosis.

One group was selected as a positive control group, three groups were fed on prednisone acetate diets containing GCs powder at the level of 2.5, 5, and 7.5% .

The biological results showed a significant improvement (P≤0.05) in values of Ca and P in serum and femur bone of osteoporotic rats fed on a basal diet containing different ratios of GCs.

Bone mineral content and bone mineral density also increased as compared to the control positive group.

Kidney and liver functions significantly (P≤0.05) improved compared to the positive control group.

The histological examination of bone confirmed a gradual improvement in all treated groups.

Peanut sweets were produced with proportions 2.5, 5, and 7.5% of GCs, sensory evaluation indicated that all peanut sweets samples have an acceptance greater than 75% .

In conclusion, the current study indicates that GCs have improved osteoporosis biomarkers in rats and can be used up to 7.5% as a supplement in the diet of osteoporosis patients.