Creatine kinase and creatine kinase-MB in acute myocardial infarction patients : a study at King Hussein Medical Center

Abstract EN

Objective : To determine the significance of measuring total creatine kinase and creatine kinase-MB levels in the diagnosis of acute myocardial infarction.

Methods: A strategy for diagnosing acute myocardial infarction was evaluated by studying 500 suspected patients aged 30-70 years.

The control group, which included 300 subjects, was randomly selected from the casualty department Investigations were carried out at Queen Alia ' Heart Institute, King Hussein Medical Center.

Total creatine kinase and creatine kinase-MB were measured in serum applying the creatine kinase, creatine kinase-MB NAC activated methods (Boehringer Mannheim's) using the Brio-10 semi autoanalyzer.

Results: In acute myocardial infarction patients, the mean value of total creatine kinase was greater than ' that", of the normal range.

Results of 25-825 U/Lfor creatine kinase (for both s exes) were obtained at "admission* Also the mean value of creatine kinase-MB (8.1-40 U / L) and % creatine kinase-MB were greater than that of the normal range in both sexes.

The maximum peak was found after 8-12 hours from the time of admission of myocardial infarction patients, both males andfemales.

Conclusions: This study demonstrated that measurement of total creatine kinase and creatine kinase-MB is currently the test of choice to confirm the diagnosis of an acute myocardial infarction.

Measurement of total creatine kinase and creatine kinase-MB every 8-12 hours is an adequate and cost- effective method for the diagnosis of acute myocardial infarction.

It was found that measurements of total creatine kinase and creatine kinase-MB are useful parameters for identifying people at high risk for acute myocardial infarction.