Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol : application to paracetamol
Other Title(s)
التقدير الطيفي للبارا-امينو فينول باستخدام تفاعل االقتران التأكسدي مع -4 كلوروريسو رسينول – تطبيق على مستحضرات الباراسيتامول
Joint Authors
al-Hafiz, Hibah Abd al-Salam
Uthman, Nabil Sabih
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 30, Issue 5 (31 May. 2021), pp.136-146, 11 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2021-05-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
A simple sensitive spectrophotometric method has been suggested for the estimation of pure p-aminophenol(p-AMPL), and p-AMPL results from the hydrolysis of paracetamol(PARL).
The suggested method is based on oxidative coupling reaction of p-AMPL with 4-chlororesorcinol (4-CLRL) and potassium periodate to produce a stable, and water-soluble coloured product with maximum orption at wavelength 556 nm.
Beer's law is followed over the range of concentration from 2 to 20 µg p-AMPL.
ml-1.
The molar orptivity value is equal to 1.0277×104 l.
mol-1cm-1.
All factors responsible for the completed reaction and highest intensity of the product have been studied, and the optimal of each factor has been selected.
The suggested method was applied in an indirect method for thedetermination of paracetamol in tablets and injection after acidic hydrolysis to p-AMPL.
The common excipients added did not interfere in the estimation of paracetamol.
The suggested method was applied in an indirect method for thedetermination of paracetamol in tablets and injection after acidic hydrolysis to p-AMPL.
The common excipients added did not interfere in the estimation of paracetamol.
American Psychological Association (APA)
al-Hafiz, Hibah Abd al-Salam& Uthman, Nabil Sabih. 2021. Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol : application to paracetamol. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 30, no. 5, pp.136-146.
https://search.emarefa.net/detail/BIM-1302569
Modern Language Association (MLA)
al-Hafiz, Hibah Abd al-Salam& Uthman, Nabil Sabih. Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol : application to paracetamol. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 30, no. 5 (2021), pp.136-146.
https://search.emarefa.net/detail/BIM-1302569
American Medical Association (AMA)
al-Hafiz, Hibah Abd al-Salam& Uthman, Nabil Sabih. Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol : application to paracetamol. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2021. Vol. 30, no. 5, pp.136-146.
https://search.emarefa.net/detail/BIM-1302569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 145-146
Record ID
BIM-1302569