Camel milk mitigates hemato-immunotoxic impacts of fenpropathrin oral intoxication in male rat

Abstract EN

Our present trial was carried out to investigate the hematological and immune related impacts of fenpropathrin (FNP) pyrethroid in male rats and to assess the ameliorating effect of camel milk (CM).

Sixty male rats were randomly separated into six equal groups (n=10).

1st control (C), 2nd corn oil (CO), 3rd camel milk (CM) groups were orally gavaged physiological saline, CO, and CM respectively at doses of 2ml/rat day after day for 60 days.

4th (FNP treated group); orally received FNP 7.06 mg/kg B.W, 5th (CM+FNP pro/co treated group); received CM two weeks prior to and along with FNP, and 6th (FNP+CM co treated group); received FNP followed by CM with the same previous doses, route, and duration.

FNP intoxication significantly decreased RBC counts, HCT, MCHC, Hb content, phagocytosis %, phagocytic index, serum lysozyme activity, and IgM levels.

Also, FNP significantly increased leukogram, platelet count, TNFα and IL6 serum levels.

CM significantly attenuates the altered indices more significantly in the (CM+FNP pro/co treated) group than the (FNP+CM co treated) group.

Spleen tissues of FNP treated group revealed marked atrophy and lymphoid elements depletion with apoptosis.

Furthermore; marked atrophy of thymic cortex, delineation of cortex and medulla with multifocal lymphocytic depletion.

It is concluded that CM significantly attenuates both hematological and immunological toxic impacts induced by FNP oral intoxication in rats.

Additionally CM pre and concurrent oral administration could lessen FNP induced alterations than CM concurrent administration only.