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Effect of diethyl nitrosamine and carbon tetra chloride induced hepatotoxicity in obese rats
Joint Authors
al-Adl, Muhammad
Salamah, Muhammad F.
Salatin, Samar M.
Marghani, Basma H.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 63, Issue 2 (31 Oct. 2019), pp.132-141, 10 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2019-10-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hepatotoxicity causes a very high mortality all over the world.
Several hepatotoxins are responsible for the development of hepatotoxicity.
This study was aimed to evaluate the potential effect of Diethyl nitrosamine (DEN)/Carbon tetra chloride (CCL4)-induced hepatotoxicity in obese rats.
Forty male albino rats were divided equally into four groups; G1; control group, G2; DEN/ CCL4 group (IP injection of DEN (200 mg/kg Bwt) followed by weekly SC injectionof CCL4 (3 mg/kg Bwt) for six weeks, G3; obese group (fed HFD) for 11 weeks&G4; DEN/ CCL4/ obese group (DEN/ CCL4 +obesity).
Serum samples of all rats were analyzed for lipid profile and liver enzymes, ALP, total & direct albumin and alpha fetoprotein.Liver tissues were collected for analysis of oxidative stress markers, gene expression of Caspase-3 expression and histopathological examination.
DEN/ CCL4 induced hepatotoxicity in G2 significantly increase serum lipid profile, liver enzymes, ALP, total & direct bilirubin, alpha-fetoprotein and liver MDA, meanwhile significantly decreased serum HDL-C, albumin, liver SOD, CAT, GSH and Caspase-3 expressionwhen compared to control group.
DEN /CCl4/ obese treated rats in G4 showed insignificantly changed lipid profile, while serum activities of ALT, ALP, as well as serum levels of total & direct bilirubin, alpha-fetoprotein, and Caspase-3 expression were significantly elevated, while AST, albumin and liver SOD were significantly decreased when comparedwith obese rats.
This study highlights the ameliorative effects of obesity in delaying the progress of toxic effects of DEN / CCL4 on liver of obese rats.
American Psychological Association (APA)
Salatin, Samar M.& Marghani, Basma H.& al-Adl, Muhammad& Salamah, Muhammad F.. 2019. Effect of diethyl nitrosamine and carbon tetra chloride induced hepatotoxicity in obese rats. Alexandria Journal of Veterinary Sciences،Vol. 63, no. 2, pp.132-141.
https://search.emarefa.net/detail/BIM-1314572
Modern Language Association (MLA)
Salatin, Samar M.…[et al.]. Effect of diethyl nitrosamine and carbon tetra chloride induced hepatotoxicity in obese rats. Alexandria Journal of Veterinary Sciences Vol. 63, no. 2 (Oct. 2019), pp.132-141.
https://search.emarefa.net/detail/BIM-1314572
American Medical Association (AMA)
Salatin, Samar M.& Marghani, Basma H.& al-Adl, Muhammad& Salamah, Muhammad F.. Effect of diethyl nitrosamine and carbon tetra chloride induced hepatotoxicity in obese rats. Alexandria Journal of Veterinary Sciences. 2019. Vol. 63, no. 2, pp.132-141.
https://search.emarefa.net/detail/BIM-1314572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 138-141
Record ID
BIM-1314572