Synthesis and characterization of novel pro drug polymers and their controlled release
Joint Authors
A., Firyal M.
Sadun A. A.
Faris H. A. M.
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 24, Issue 9 (31 Dec. 2016), pp.2527-2542, 16 p.
Publisher
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
16
Main Subjects
Abstract EN
Many crosslinked polymers have been prepared through many steps, including the esterification of triethanolamine with maleic anhydride toproduce compound (A1) then the carboxylic acid groups of (1) were converted to amide attachments when they reacted with some drug-NH2, The unsaturated maleamides (A2-A5) were polymerized free radically by using dibenzoyl peroxide as an initiator at 90°C.
such as Amoxicillin, 4-Amino antipyrine, Cephalexin, and Procaine drug polymers (A6-A9).All prepared monomers and polymers have been characterized by FTIR and 1H-NMR and UV.
Spectroscopies.
The swelling percentage is higher than 90%.
The rate of hydrolysis of a controlled drug release was studied in different pH values at 37°C, at λmax, 270nm and 220nm in basic and acidic medium.
TGA and DSC are recorded; It isappeared that the prepared drug polymers have high thermal properties.
American Psychological Association (APA)
A., Firyal M.& Sadun A. A.& Faris H. A. M.. 2016. Synthesis and characterization of novel pro drug polymers and their controlled release. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 24, no. 9, pp.2527-2542.
https://search.emarefa.net/detail/BIM-1314670
Modern Language Association (MLA)
A., Firyal M.…[et al.]. Synthesis and characterization of novel pro drug polymers and their controlled release. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 24, no. 9 (2016), pp.2527-2542.
https://search.emarefa.net/detail/BIM-1314670
American Medical Association (AMA)
A., Firyal M.& Sadun A. A.& Faris H. A. M.. Synthesis and characterization of novel pro drug polymers and their controlled release. Journal of Babylon University : Journal of Applied and Pure Sciences. 2016. Vol. 24, no. 9, pp.2527-2542.
https://search.emarefa.net/detail/BIM-1314670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 2542
Record ID
BIM-1314670