Determination of serum trace elements and hematological parameters in lymphoma patients receiving chemotherapy

Abstract EN

Background Trace elements are essential components of biological structures, some of them play an important role as anticancer and others can be toxic at concentrations beyond those necessary for their biological functions.

Aim The objective is to examine changes in serum concentration of trace elements (Cobalt (Co), Germanium (Ge), Molybdenum (Mo), Nickel (Ni) and Vanadium (V)), Mg and hematological changes in Hodgkin and Non-Hodgkin lymphoma patients receiving therapy.

Materials and methods The study was included 25 patients with Non-Hodgkin lymphoma (NHL) and 25 patients with Hodgkin lymphoma (HL) as compared with 50 healthy subjects.

Serum concentration of trace elements are measured by flame atomic absorption spectrophotometer.

The total leukocyte count (TLC), hemoglobin concentration (Hb) and packed cell volume or hematocrit (Hct) are determined.

Results Statistical analysis of data demonstrated significant decrease (p<0.001) in Mg and Co concentration and (p<0.01) in Ge concentration in patients with lymphomas receiving therapy as compared with healthy adults.

V and Ni concentrations are significantly increased (p<0.001) in patients with lymphomas receiving therapy as compared with healthy adults.

The study shows significant decrease (p<0.05) in Hb concentration and Hct percentage in patients with lymphomas receiving chemotherapy as compared with healthy subjects.

It revealed significant decrease (p<0.005) in female patients with lymphoma who receive chemotherapy.

Significant decrease (p<0.001) in TLC in patients with lymphomas receiving therapy as compared with healthy adults are observed.

Conclusion Lymphoma patients receiving therapy are often low in Mg, Ge and Co levels while Ni and V levels are high in patients with Hodgkin and Non-Hodgkin lymphoma.

There is a significant decreased in TLC in patients with Hodgkin and Non-Hodgkin lymphoma whose are receiving chemotherapy..

Anemia occurred in patient with lymphomas as a side effect of chemotherapy.