تأثير التعرض لسيلينيت الصوديوم مع الغذاء في مستويات هرمونات الدرقية لذكور الجرذان الناضجة

Abstract EN

This study was designed to investigate some effects of mineral selenium when add to food as sodium selenite for healthy male white rats with concentrations (125, 250, 500) part per million from sodium selenite for periods 20 and 30 days for measurement levels both of thyroid stimulating hormones , thyroxine and Triiodothyronine hormones in the rats .

Fourty Swiss male rats from genius Rattus norvigicus with aged three -half month were used in this study weighted (270 – 230) grams were divided into equal four groups given diet have three level of sodium selenite (500, 250, 125) part per million.

This study includes evaluation of the effects of weight again and thyroid hormones levels for periods 20 and 30 days.

The following findings were attained: There was no significant differences in the weights of the treated animals with sodium selenite for 20 days with concentration (125 ppm) while there was a significant decrease (P<0.05) in the concentrations (250 & 500 ppm).

There was a significant decrease (P<0.05) in concentrations (125, 250 & 500 ppm) for 30 days as compared with the control group.

The treatment with the sodium selenite caused significant increase (P<0.05) in the level of thyroid stimulating hormone in concentration (500 p.p.m.) for 20 days, while there was significant increase (P>0.05) in the treated for 30 days in concentrations (125, 250 & 500 p.p.m.) as compared with the control group.

There was non-significant decrease (P>0.05) in the thyroxine hormone level in the concentrations (250 & 500 p.p.m.) for 20 days and there was a significant decrease (P<0.05) in concentrations (125, 250, 500 p.p.m.) for 30 days as compared with the control group.

There was non-significant decrease (P>0.05) in the triiodothyronine hormone level in concentrations (125, 250, 500 p.p.m.) for 20 days and a significant decrease (P<0.05) for 30 days in concentrations (125, 250, 500 p.p.m.) as compared with the control group.