The role of il-4 and il-10 among chronic hepatitis patients

Joint Authors

al-Jabburi, Raid F.
Abbas, Rahim Tumah
Hasan, Amaal Mirza

Source

Journal of Babylon University : Journal of Applied and Pure Sciences

Issue

Vol. 27, Issue 5 (31 Dec. 2019), pp.54-65, 12 p.

Publisher

University of Babylon

Publication Date

2019-12-31

Country of Publication

Iraq

No. of Pages

12

Main Subjects

Engineering & Technology Sciences (Multidisciplinary)

Abstract EN

Background: Hepatitis viruses are common cause of viral hepatitis, it has a varied distribution among people, it has more than five common types: Hepatitis A, B, C, D, E.

Hepatitis B,C,&D occurred by parenteral route.

Hepatitis E occurres specially in pregnant women by feco-oral route.

Interleukin-4 (IL-4) protect human hepatocellular cell line from apoptosis and suppresses the expression and replication of hepatitis B virus.

Exposure to HCV antigens increased L-10 production by polymorphonuclear cells and T cells.

Aim of study: To monitor the significance of IL-4 and IL-10 among patients with chronic HBV and HCV, to find the frequency of confirmed hepatitis virus in Babylon City and to compare between their percentages and possible cause of transmission and method to prevent it Materials and Methods: A total number of 18 patients for each group of hepatitis B and C were taken to estimate of IL-4 and IL-10 which compared with 14 apparently healthy control group in Central Public Health Lab/ Babylon during the period from January-June, 2008.

Results: The results showed highly significant decrease in IL-4 in both groups in comparison to control group while IL-10 showed highly significant increase in both group in comparison to control group.

Conclusions: Immune factors are essential in the consequence of chronic HBV and HCV infection.

Serum IL4 might be used as a laboratory parameter to indirectly assess liver damage instead of invasive histopathological examination.

IL-10 might influence HCV and HBV infections susceptibility due to its anti-inflammatory action.

IgG4 might further aggravate the disease course of HBV and HCV infection caused by IL-10.

American Psychological Association (APA)

al-Jabburi, Raid F.& Abbas, Rahim Tumah& Hasan, Amaal Mirza. 2019. The role of il-4 and il-10 among chronic hepatitis patients. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 27, no. 5, pp.54-65.
https://search.emarefa.net/detail/BIM-1315073

Modern Language Association (MLA)

al-Jabburi, Raid F.…[et al.]. The role of il-4 and il-10 among chronic hepatitis patients. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 27, no. 5 (2019), pp.54-65.
https://search.emarefa.net/detail/BIM-1315073

American Medical Association (AMA)

al-Jabburi, Raid F.& Abbas, Rahim Tumah& Hasan, Amaal Mirza. The role of il-4 and il-10 among chronic hepatitis patients. Journal of Babylon University : Journal of Applied and Pure Sciences. 2019. Vol. 27, no. 5, pp.54-65.
https://search.emarefa.net/detail/BIM-1315073

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 62-65

Record ID

BIM-1315073