Effect of fourteen antibiotics on Klebsiella pneumonia and Proteus mirabilis strains isolated from human urinary tract

Abstract EN

The urinary tract is normally sterile and resistant to bacterial colonization despite frequent contamination of the distal urethra with colonic bacteria.

Klebsiella pneumonia, Proteus mirabilis, and other coliform bacteria are the most frequently implicated pathogens.

The prevalence of antibiotic-resistant bacteria has increased and multi-drugresistant strains were emerged in many species and cause diseases in humans.

This study was performed to determine the patterns of multi and single antibiotic resistant strains of two important urinary tract pathogens.

From 236 urine specimens 32 strains of Klebsiella pneumonia and 11 strains of Proteus mirabilis were isolated with infection rate reached 9.8% and 3.36% respectively.

Strains of Klebsiella pneumonia showed single-antibiotic-resistance ranged between 100% for Cephaloridin, and Cloxacillin and 6% for Gentamycin.

Whereas Proteus mirabilis showed high resistance to single antibiotic ranged between 100% for Erythromycin, Cloxacillin, and Cephaloridin and low resistance (36%) for Naldixic acid and Nitrofurantoin.

Proteus mirabilis gave high multi-resistance (100%) represented by one strain with two frequencies (13.33%) and resistant to 13 antibiotic.

K.

pneumonia gave 6 strains classified into two patterns; first includes four strains with two frequencies (13.33%) for each.

Each strain was resistant to 9, 10, 11, and 12 antibiotics.

The second pattern includes two strains which are resistant to 13 antibiotics for each but one strain gave two frequencies (13.33%) and the second showed 20% frequency.

In conclusion, it is important to produce new effective antibiotics and used them against these multi-resistant strains.

More rational use of antibiotics and decrease abuse of antibiotics are needed.