Curcumin attenuated oxidative stress and inflammation on hepatitis induced of by fluvastatin in female albino rats
Joint Authors
Salama, Afrah F.
Tusun, Ihab M.
Abu Khudayr, Rasha H.
al-Ghannam, Muhammad E.
al-Dasuqi, Samar M.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 62, Issue 1 (31 Jul. 2019), pp.102-115, 14 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The current study was planned to investigate the hepatoprotective effect of curcumin (Cr) against oxidative stress insults characteristic for hepatitis induced by Fluvastatin (F) in female rats.
Animals were divided into Three groups: group1 (negative control), group2 (F-control), group3 (F+Cr).
Rats were received F for first 10 days while received Cr for all 20 days (duration of experimental period).
Results obtained showed that F significantly increased alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AlP), gamma glutamyl transpeptidase (γ-GTP), total bilirubin, malondialdehyde (MDA), tumor necrosis factor α protein (TNFα), tumor growth factorβ1 (TGFβ1), nuclear factor Kappa B (NFKB), cyclooxygenase-1 and 2 (COX-1 and 2), while, decreased the levels of albumin and total protein, reduced glutathione (GSH), Glutathione peroxidase (GPx), catalase (CAT) and interleukin-10 protein (IL-10).
Liver histological and immune-histochemical investigations of rats administered F showed sever congestion in portal vein associated with fibrosis and inflammatory cells infiltration.
Also, collagen-I stained cells were found in the portal area and the central vein.
On the other hand, animals treated with curcumin showed improvements for these parameters as well as in the histological and immune-histochemical feature of the liver.
Therefore, the present results indicated that curcumin could reduce oxidative stress and inflammation characterizing hepatitis.
American Psychological Association (APA)
Abu Khudayr, Rasha H.& al-Ghannam, Muhammad E.& Salama, Afrah F.& Tusun, Ihab M.& al-Dasuqi, Samar M.. 2019. Curcumin attenuated oxidative stress and inflammation on hepatitis induced of by fluvastatin in female albino rats. Alexandria Journal of Veterinary Sciences،Vol. 62, no. 1, pp.102-115.
https://search.emarefa.net/detail/BIM-1323528
Modern Language Association (MLA)
Abu Khudayr, Rasha H.…[et al.]. Curcumin attenuated oxidative stress and inflammation on hepatitis induced of by fluvastatin in female albino rats. Alexandria Journal of Veterinary Sciences Vol. 62, no. 1 (Jul. 2019), pp.102-115.
https://search.emarefa.net/detail/BIM-1323528
American Medical Association (AMA)
Abu Khudayr, Rasha H.& al-Ghannam, Muhammad E.& Salama, Afrah F.& Tusun, Ihab M.& al-Dasuqi, Samar M.. Curcumin attenuated oxidative stress and inflammation on hepatitis induced of by fluvastatin in female albino rats. Alexandria Journal of Veterinary Sciences. 2019. Vol. 62, no. 1, pp.102-115.
https://search.emarefa.net/detail/BIM-1323528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 112-115
Record ID
BIM-1323528