Acetamiprid, insecticide-induced oxidative damage on reproductive parameters male rats
Joint Authors
Ibrahim, Hisham Z.
al-Banna, Sabah G.
Abd al-Rafii, Ahmad
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 64, Issue 1 (31 Jan. 2020), pp.63-68, 6 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Acetamiprid is a neoncotinoid insecticide that acts as agonist to the nicotinic acetylcholine receptor used as insecticide in crops and control fleas on dogs and cats.
The objective of this study was to evaluate the acetamiprid toxicity of oral administered on the reproductive system, to assess the role of oxidative stress inducing damage to the testes in male rats.
The low dose equal 1/4 of LD50 and high dose equal 1/2 of LD50.
Doses of acetamiprid adjusted according to rat's body weights.
The results revealed that acetamiprid at high dose significantly (P<0.05) increased thiobabituric acid reactive substances (TBARS) resulting in significantly (P<0.05) decrease reduced glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPx) and glutathione reductase (GR) in testes homogenate.
Also, administratim of acetamiprid significantly increased catalase while, there was insignificant change in superoxide dismutase (SOD).
Acetamiprid at low and high doses significantly (P<0.05) decreased plasma testosterone level, sperm count, viability, motility, fructose level, and significantly (P<0.05) increased abnormal sperms, altered acrosome and abnormal DNA.
Acetamiprid induce oxidative stress leading to decrease antioxidant enzymes and damage sertoil cells resulting in decreasing testosterone level and effect on fertility.
Moreover, the histological investigation revealed that exposure to acetamiprid disorganized stratification of spermatogonia, primary and secondary spermatocytes in some tubules sheeding of sperm cells into lumina, necrosis in tubules and reduction of the primary and secondary spermatids.
In conclusion, it seems that acetamiprid induces adverse effect at high dose level but the low dose level may not and short-term exposure make adverse effect.
So, it can recommend using this insecticide as long as the recommended dose.
American Psychological Association (APA)
Ibrahim, Hisham Z.& al-Banna, Sabah G.& Abd al-Rafii, Ahmad. 2020. Acetamiprid, insecticide-induced oxidative damage on reproductive parameters male rats. Alexandria Journal of Veterinary Sciences،Vol. 64, no. 1, pp.63-68.
https://search.emarefa.net/detail/BIM-1324201
Modern Language Association (MLA)
Ibrahim, Hisham Z.…[et al.]. Acetamiprid, insecticide-induced oxidative damage on reproductive parameters male rats. Alexandria Journal of Veterinary Sciences Vol. 64, no. 1 (Jan. 2020), pp.63-68.
https://search.emarefa.net/detail/BIM-1324201
American Medical Association (AMA)
Ibrahim, Hisham Z.& al-Banna, Sabah G.& Abd al-Rafii, Ahmad. Acetamiprid, insecticide-induced oxidative damage on reproductive parameters male rats. Alexandria Journal of Veterinary Sciences. 2020. Vol. 64, no. 1, pp.63-68.
https://search.emarefa.net/detail/BIM-1324201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 67-68
Record ID
BIM-1324201