Factors predictive of papillary thyroid cancer (PTC)‎ recurrence post total thyroidectomy and radioiodine ablation : a single-center experience in the Jordanian Royal Medical services

Joint Authors

al-Khawlidah, Khalid
Jabali, Islam
Atiyyah, Ula
Zabun, Anas
al-Asad, Raniya
al-Zubi, Mahmud
Ashukaybi, Umar Y.
Halasah, Mays
al-Adwan, Hamzah
al-Zurayqat, Abd Allah

Source

Journal of the Royal Medical Services

Issue

Vol. 28, Issue 3 (31 Dec. 2021), pp.54-59, 6 p.

Publisher

The Royal Medical Services Jordan Armed Forces

Publication Date

2021-12-31

Country of Publication

Jordan

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Aim: to assess the factors predictive of PTC recurrence after total thyroidectomy and radioiodine ablation using a retrospective analysis of patients treated for thyroid cancer by the Jordanian Royal Medical Services (JRMS).

Methods: 243 patients (56 men and 186 women) were included in the study (at King Hussein Medical Center) between January 2009-December 2017 with a mean age of 40 years.

All patients had papillary thyroid cancer.

Fifty-eight percent (58%) underwent a one-stage total thyroidectomy, and 42% underwent a two-stage thyroidectomy and all patients received I131 Radio-Iodine ablation.

Univariate regression analyses were used to study factors that may influence the risk of recurrent disease.

Results: There was no statistically significant difference for sex, initial thyroid surgical management, vascular invasion, positive surgical margin, or the dose of I131 Radio-Iodine ablation dose.

Tumour recurrence was found in 27% of patients younger than 40 years old at the time of diagnosis, which was found to be significant (P=0.009).

It was noted that disease recurrence was more frequent in patients with T2-T4 tumour stages [13% (12 out of 92 patients) with T2, 41% (32 out of 78 patients) with T3, and 80% (12 out of 15 patients) with T4 tumours]; this was statistically significant (P=0.0001).

The last characteristic that showed a significant risk for recurrence was lymphatic invasion, which was noted in 51% (46 out of 90 patients with disease recurrence) (P=0.008).

Conclusion: Our cohort study results show that patients <40 years old, with large tumour size (T), and lymphatic invasion have a significantly higher recurrence rate.

Gender, presence of vascular invasion, positive tumour margins, and radio-iodine ablation may have an impact on the chance of recurrence but were not statistically significant

American Psychological Association (APA)

al-Zurayqat, Abd Allah& al-Adwan, Hamzah& Atiyyah, Ula& Jabali, Islam& Zabun, Anas& al-Khawlidah, Khalid…[et al.]. 2021. Factors predictive of papillary thyroid cancer (PTC) recurrence post total thyroidectomy and radioiodine ablation : a single-center experience in the Jordanian Royal Medical services. Journal of the Royal Medical Services،Vol. 28, no. 3, pp.54-59.
https://search.emarefa.net/detail/BIM-1326113

Modern Language Association (MLA)

al-Khawlidah, Khalid…[et al.]. Factors predictive of papillary thyroid cancer (PTC) recurrence post total thyroidectomy and radioiodine ablation : a single-center experience in the Jordanian Royal Medical services. Journal of the Royal Medical Services Vol. 28, no. 3 (Dec. 2021), pp.54-59.
https://search.emarefa.net/detail/BIM-1326113

American Medical Association (AMA)

al-Zurayqat, Abd Allah& al-Adwan, Hamzah& Atiyyah, Ula& Jabali, Islam& Zabun, Anas& al-Khawlidah, Khalid…[et al.]. Factors predictive of papillary thyroid cancer (PTC) recurrence post total thyroidectomy and radioiodine ablation : a single-center experience in the Jordanian Royal Medical services. Journal of the Royal Medical Services. 2021. Vol. 28, no. 3, pp.54-59.
https://search.emarefa.net/detail/BIM-1326113

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 58-59

Record ID

BIM-1326113