Evaluation of the effect cholesterolemia on general health condition

Abstract EN

This study aimed to evaluate the effect cholesterolemia on general health condition, and investigate the effect of some vegetables such as watermelon, green pepper, rocket and their blend, level to combat with hypercholesterolemia via determation of some biological parameters, biochemical parameters of serum liver and renal function parameters.

The study was carried on fourty male adult albino rats, weighting(110 ±5) g each, feeding continued for 8 weeks.Watermelon skine,green pepper, rocket and their blend was added to the diet of rats at two levels ,5% and 10% (to basal diet).Body weight and food intake were recorded weekly.

At the end of the experiment, all rats were weighed for calculation of body weight gain % and food efficiency ratio.

In comparison with control (+ve) group, there was a decrease in cholesterol, TG, LDLC, TL.

and R.

r in all hypercholesterolemic rats groups treated with vegetables but there was an increase in HDL.c.

As for liver function the results indicated that all groups were significantly lower in enzymes actives than positive control.The results proved also the decreasing of renal function parameters (creatinine and urea) in all vegetables treated rats groups.

In compared with control (+ve) group, the value of hemoglobin level was increased in all vegetable treated rats groups.On the other hand the histopathological examination or control (+ve) group, of liver tissue showed focal degeneration of hepatic cells and heamorrahge between hebatocytes.

The heart tissue showed necrosis of cardiac muscle fibers, odema and inflammatory cells between cardiac muscle fibers.

Vegetables, specially watermelon, pepper, rocket and the blend (2.5),(5%) groups showed improvement of pathological changes and the structure was more or less around normal, indicating the value of vegetables and confirming the biological and biochemical analyses.

Thus study recommended to Among vegetable sources of value in reducing T.L., T.C.,TG, LDL &VLDL in serum, watermelon skin , green pepper and rocket are recommended.