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The effect of metformin and ginseng on Alloxan-induced diabetic rats : hematological, biochemical and histopathological studies
Joint Authors
Hashim, Muhammad Abd al-Azim
Jad al-Karim, Dina R. S.
Tuhami, Husam G.
Awdah, Samah S.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 55, Issue 1 (31 Oct. 2017), pp.60-66, 7 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The current study was performed to evaluate the anti-diabetic action of metformin and ginseng in alloxan-induced diabetes in rats.
Forty male albino rats were used in this work, ten rats were left without any treatment and kept as a control, the remaining thirty rats were injected with alloxan to induce diabetes and then divided into three equal groups, the first group was kept without any treatment during period of the experiment, the second one treated with metformin (300 mg/kg B.Wt.) and the third one treated with ginseng at dose level of 250 mg/kg B.Wt.
for 30 consecutive days.
The results showed a significant changes in the hematological parameters, fasting blood glucose level, glycosylated hemoglobin (HbA1C) besides the activity of liver enzymes (aspartate aminotranseferase (AST), alanine aminotranseferase (ALT) and gamma glutamyltransferase (GGT)) and level of total protein in addition to lipid profile (Triglyceride (TG),total cholesterol (TC), very low density lipoprotein (VLDL) and low density lipoprotein (LDL) except high density lipoprotein (HDL)) in all groups compared to control group.
The liver and pancreas of all groups were collected and examined histopathologically.
Metformin and ginseng have ameliorative effect on biochemical and histopathological alterations caused by hyperglycemia.
From our data it could be concluded that ginseng can be used as an effective anti-hyperglycemic and antioxidantagent.
American Psychological Association (APA)
Jad al-Karim, Dina R. S.& Awdah, Samah S.& Tuhami, Husam G.& Hashim, Muhammad Abd al-Azim. 2017. The effect of metformin and ginseng on Alloxan-induced diabetic rats : hematological, biochemical and histopathological studies. Alexandria Journal of Veterinary Sciences،Vol. 55, no. 1, pp.60-66.
https://search.emarefa.net/detail/BIM-1327626
Modern Language Association (MLA)
Jad al-Karim, Dina R. S.…[et al.]. The effect of metformin and ginseng on Alloxan-induced diabetic rats : hematological, biochemical and histopathological studies. Alexandria Journal of Veterinary Sciences Vol. 55, no. 1 (Oct. 2017), pp.60-66.
https://search.emarefa.net/detail/BIM-1327626
American Medical Association (AMA)
Jad al-Karim, Dina R. S.& Awdah, Samah S.& Tuhami, Husam G.& Hashim, Muhammad Abd al-Azim. The effect of metformin and ginseng on Alloxan-induced diabetic rats : hematological, biochemical and histopathological studies. Alexandria Journal of Veterinary Sciences. 2017. Vol. 55, no. 1, pp.60-66.
https://search.emarefa.net/detail/BIM-1327626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 65-66
Record ID
BIM-1327626