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Association of urinary vitamin d binding protein and neutrophil gelatinase-associated lipocalin with steroid responsiveness in idiopathic nephrotic syndrome of childhood
Joint Authors
Rajappa, Medha
Mohanraj, Palani Selvam
Choudhary, Amit
Krishnamurthy, Sriram
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 31, Issue 5 (31 Oct. 2020), pp.946-956, 11 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2020-10-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
Idiopathic nephrotic syndrome (NS) is one of the most common kidney diseases of childhood.
In this study, we assessed urine Vitamin-D binding protein (VDBP) and neutrophil gelatinase-associated lipocalin (NGAL) levels as a predictor of steroid responsiveness in idiopathic NS.
This cross-sectional study included children with steroid-resistant NS (SRNS) (n = 28), steroid-sensitive NS (SSNS) (n = 28), and healthy controls (n = 28).
Urine levels of VDBP and NGAL were measured using a commercially available ELISA kit and normalized to urine creatinine (Cr).
Urine microalbumin (MALB) was measured using nephelometer, and MALB/Cr was calculated.
Urine Vitamin-D binding protein (uVDBP) and urine neutrophil gelatinase-associated lipocalin (uNGAL) levels were statistically significantly higher (P < 0.001) in patients with SRNS (701.12 ± 371.64 ng/mL and 28.42 ± 15.40 ng/mL, respectively) than in patients with SSNS (252.87 ± 66.34 ng/mL and 8.86 ± 5.54 ng/mL, respectively) and normal controls (34.74 ± 14.10 ng/mL and 6.79 ± 1.32 ng/mL, respectively).
Estimated glomerular filtration rate shows a significant negative correlation with MALB/Cr, uVDBP, and uNGAL.
However, uVDBP and uNGAL showed a much higher discriminatory ability for differentiating SRNS from MALB/Cr.
uVDBP and uNGAL at the cutoff value of 303.81 and 13.1 ng/mL, respectively, yielded the optimal sensitivity (82% and 86%) and specificity (78% and 89%) to distinguish SRNS from SSNS.
Urine levels of VDBP and NGAL can predict steroid responsiveness in patients with idiopathic NS.
American Psychological Association (APA)
Choudhary, Amit& Mohanraj, Palani Selvam& Krishnamurthy, Sriram& Rajappa, Medha. 2020. Association of urinary vitamin d binding protein and neutrophil gelatinase-associated lipocalin with steroid responsiveness in idiopathic nephrotic syndrome of childhood. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 5, pp.946-956.
https://search.emarefa.net/detail/BIM-1331673
Modern Language Association (MLA)
Choudhary, Amit…[et al.]. Association of urinary vitamin d binding protein and neutrophil gelatinase-associated lipocalin with steroid responsiveness in idiopathic nephrotic syndrome of childhood. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 5 (Sep. / Oct. 2020), pp.946-956.
https://search.emarefa.net/detail/BIM-1331673
American Medical Association (AMA)
Choudhary, Amit& Mohanraj, Palani Selvam& Krishnamurthy, Sriram& Rajappa, Medha. Association of urinary vitamin d binding protein and neutrophil gelatinase-associated lipocalin with steroid responsiveness in idiopathic nephrotic syndrome of childhood. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 5, pp.946-956.
https://search.emarefa.net/detail/BIM-1331673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 955-956
Record ID
BIM-1331673