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Potential ameliorative effects of alpha lipoic acid and silymarin on thioacetamide-induced hepatic damage in rats
Joint Authors
Hashim, Muhammad Abd al-Azim
Khafajah, Asma F.
Salamah, Alya R.
Udah, Samah S.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 54, Issue 1 (31 Jul. 2017), pp.117-126, 10 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study was designed to study the ameliorative role of alpha lipoic acid (ALA) and silymarin (SIL) against thioacetamide (TAA)-induced hepatic damage.
Sixty male albino rats were randomly separated into 6 groups (n=10); control group, TAA-treated group: received intraperitoneal injection of TAA 250 mg/kg bwt/day three times a week, ALA-treated group: received ALA 100 mg/kg bwt/day) orally three times a week, SIL-treated group: received SIL 100 mg/kg bwt/day orally three times a week, TAA+ALA-treated group, and TAA+SIL-treated group at the same previous doses and routes for ten weeks.
Results showed that TAA induced a significant elevation in total and direct bilirubin, total cholesterol and triglycerides levels and serum liver enzymes after four and ten weeks of the treatments.
While the serum levels of total proteins, albumin and high density lipoprotein-cholesterol revealed a significant decrease.
TAA injection resulted in an increase in the hepatic lipid peroxidation and decreased levels of antioxidant biomarker.
Histopathologically, TAA revealed marked degenerative, necrotic and fibrotic alterations in the liver, particularly during ten weeks post-treatment.
ALA and SIL- treatment ameliorated TAA-induced oxidative damage, alterations in the liver function tests and liver histopathology.
However, ALA demonstrated better hepatic protection against TAA-induced liver damage as compared to SIL.
The study clearly concluded that ALA has more powerful antioxidant properties than SIL.
American Psychological Association (APA)
Salamah, Alya R.& Udah, Samah S.& Khafajah, Asma F.& Hashim, Muhammad Abd al-Azim. 2017. Potential ameliorative effects of alpha lipoic acid and silymarin on thioacetamide-induced hepatic damage in rats. Alexandria Journal of Veterinary Sciences،Vol. 54, no. 1, pp.117-126.
https://search.emarefa.net/detail/BIM-1332378
Modern Language Association (MLA)
Salamah, Alya R.…[et al.]. Potential ameliorative effects of alpha lipoic acid and silymarin on thioacetamide-induced hepatic damage in rats. Alexandria Journal of Veterinary Sciences Vol. 54, no. 1 (Jul. 2017), pp.117-126.
https://search.emarefa.net/detail/BIM-1332378
American Medical Association (AMA)
Salamah, Alya R.& Udah, Samah S.& Khafajah, Asma F.& Hashim, Muhammad Abd al-Azim. Potential ameliorative effects of alpha lipoic acid and silymarin on thioacetamide-induced hepatic damage in rats. Alexandria Journal of Veterinary Sciences. 2017. Vol. 54, no. 1, pp.117-126.
https://search.emarefa.net/detail/BIM-1332378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 124-126
Record ID
BIM-1332378