Some pharmacodynamic studies on ampicillin and enrofloxacin in male rats

Abstract EN

The present study was conducted to evaluate some pharmacodynamic effects of Enrofloxacin and /or Ampicillin each alone and their concomitant administration in male rats.

Therefore, sixty mature male albino rats were used and divided into 4 equal groups, each of 15 rats.

The first group was kept as a control and rats were subcutaneously injected with distal water at dose of 2 ml./kg.

b.wt.

The second group was injected subcutaneously with Ampicillin at a dose of 40 mg/kg.

b.wt.

twice daily with interval of 6 hours for 5 successive days .

The third group was injected subcutaneously with Enrofloxacin at a dose of 18 mg / kg.

b.wt.

once daily for 5 successive days .The fourth group was treated with Enrofloxacin (13.5 mg /kg b.w.

s/c) once daily concomitantly with Ampicillin (30 mg/kg.b.wt.s.c.) which is repeated after 6 hours from the first dose for 5 successive days.

Five rats from each control and treated groups were killed at 2 nd, 4 th and 8th weeks from the beginning of drug administration.

The obtained results showed that administration of Ampicillin and / or Enerofloxcin each alone and their concomitant administration induced a variety of side effects on male reproduction as reduction of testes, epididymis, and accessory sex organs weights , change in sperm characters, decreased sperm count and motility, and increased the sperm abnormalities.

Also, there were some biochemical alterations in the hepatic and renal function.

Moreover, these drugs induced some histo-pathological alterations in reproductive organs, liver and kidney.