ACE gene polymorphism in coronary artery disease in West Bank, Palestine
Joint Authors
Saghir, Sabri
Rajab, Raghd K.
Husayni, Ayman
Darwish, Ala al-Din Muhammad
Source
Hebron University Research Journal : Natural Sciences
Issue
Vol. 9, Issue - (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hebron University Deanship of Scientific Research
Publication Date
2020-12-31
Country of Publication
Palestine (West Bank)
No. of Pages
10
Main Subjects
Abstract EN
Heart disease is the most hazardous chronic disease that leads to death worldwide.
Hypertension is one of the most risk factors that leads to CVD.
This study has been conducted to examine the relationship between a genetic polymorphism in the angiotensin gene and coronary heart disease, and the correlation of this polymorphism with environmental and nutritional risk factors.
A case-control study has been conducted involving 100 CAD patients and 100 healthy individuals as a control group.
DNA was isolated from patient's peripheral blood, and angiotensin-converting enzyme (ACE) I/D gene polymorphism was assayed by polymerase chain reaction (PCR).
The results showed that the ACE I/D polymorphism distribution was as follows: Genotype frequencies of DD, II, and DI among cases were 0.42, 0.21, 0.37; respectively.
There was a significant association between the studied environmental and nutritional factors and the incidence of CAD I/D especially BMI (≥ 25), cigarette smoking, and family history.
The general health level of society can be improved by modifying lifestyle like eating DASH diet (dietary approach to stop hypertension), increasing physical activity and avoiding smoking and processed food.
The study emphasizes the possibility of early detection of heart disease risk by using the ACE gene polymorphism test.
American Psychological Association (APA)
Saghir, Sabri& Darwish, Ala al-Din Muhammad& Rajab, Raghd K.& Husayni, Ayman. 2020. ACE gene polymorphism in coronary artery disease in West Bank, Palestine. Hebron University Research Journal : Natural Sciences،Vol. 9, no. -, pp.1-10.
https://search.emarefa.net/detail/BIM-1332705
Modern Language Association (MLA)
Saghir, Sabri…[et al.]. ACE gene polymorphism in coronary artery disease in West Bank, Palestine. Hebron University Research Journal : Natural Sciences Vol. 9 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1332705
American Medical Association (AMA)
Saghir, Sabri& Darwish, Ala al-Din Muhammad& Rajab, Raghd K.& Husayni, Ayman. ACE gene polymorphism in coronary artery disease in West Bank, Palestine. Hebron University Research Journal : Natural Sciences. 2020. Vol. 9, no. -, pp.1-10.
https://search.emarefa.net/detail/BIM-1332705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-10
Record ID
BIM-1332705