A modified regimen of methylprednisolone, cyclophosphamide, and mycophenolic acid for severe IgA vasculitis with nephritis in a child
Joint Authors
Ambarsari, Cahyani Gita
Pardede, Sudung Oloan
Grace, Angela
Saraswati, Meilania
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 31, Issue 5 (31 Oct. 2020), pp.1117-1124, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2020-10-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
IgA vasculitis with nephritis (IgAVN), which was formerly known as Henoch– Schonlein purpura nephritis, commonly manifests with mild symptoms.
However, in rare circumstances, IgAVN in children can progress to kidney failure.
Despite the successful treatment of severe IgAVN with a combination of immunosuppressive medications including cortico- steroids, no consensus has been established for IgAVN treatment.
Here, we present a case of severe IgAVN in an eight-year-old Indonesian boy who was treated with simultaneous methylprednisolone, cyclophosphamide, and mycophenolic acid.
He experienced recovery of kidney function within one month, while proteinuria resolved in five months, and hematuria resolved within a year after treatment initiation.
No recurrences were noted during the two-year follow-up.
Although our immunosuppressive regimen may seem very potent, it was shown to have tolerable side effects and could be beneficial for kidney recovery.
Importantly, they have also been shown to prevent progression to chronic kidney disease in children with severe IgAVN.
American Psychological Association (APA)
Pardede, Sudung Oloan& Grace, Angela& Saraswati, Meilania& Ambarsari, Cahyani Gita. 2020. A modified regimen of methylprednisolone, cyclophosphamide, and mycophenolic acid for severe IgA vasculitis with nephritis in a child. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 5, pp.1117-1124.
https://search.emarefa.net/detail/BIM-1332849
Modern Language Association (MLA)
Pardede, Sudung Oloan…[et al.]. A modified regimen of methylprednisolone, cyclophosphamide, and mycophenolic acid for severe IgA vasculitis with nephritis in a child. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 5 (Sep. / Oct. 2020), pp.1117-1124.
https://search.emarefa.net/detail/BIM-1332849
American Medical Association (AMA)
Pardede, Sudung Oloan& Grace, Angela& Saraswati, Meilania& Ambarsari, Cahyani Gita. A modified regimen of methylprednisolone, cyclophosphamide, and mycophenolic acid for severe IgA vasculitis with nephritis in a child. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 5, pp.1117-1124.
https://search.emarefa.net/detail/BIM-1332849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1123-1124
Record ID
BIM-1332849