Study of serum spexin level in obese and non-obese type 2 diabetic patient
Joint Authors
Mashal, Yasamin S.
Bakr, Ata M.
al-Bayyumi, Azzah A.
Abbas, Najla E.
Source
Suez Canal University Medical Journal
Issue
Vol. 25, Issue 1 (31 Mar. 2022), pp.92-99, 8 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2022-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : spexin is a peptide, which is discovered as an important regulatory adipokine in obesity, insulin resistance (IR), and diabetes.
aim : to evaluate serum spexin levels in type-2 diabetic obese patients in comparison to its levels in non-obese diabetic (NOD) and to assess its relation-ship to IR and glycemic control.
patients and methods : a total of 20 NOD (group 1), 22 obese non-diabetic (OND) (group 2), and 24 obese diabetic patients (OD) (group 3), with an average age of 43.8 ± 8.9, 49 ± 8.8, 45.1 ± 11.6 years respectively, and 20 age and sex-matched healthy participants (control group) were included.
height and weight were measured using standard techniques.
glucose levels, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting insulin (FI), calculation of homeostasis model assessment insulin resistance (HOMA-IR), and spexin levels were measured in each patient.
Results : the median serum spexin levels were significantly lower in the OD than in the other groups and lower in the nod and OND than in the non-obese non-diabetic (NOND) (p < 0.001).
spexin level at a cutoff value ≤ 0.70 can significantly discriminate OD from NOND.
spexin levels were negatively correlated with age, body mass index (BMI), LDL-C, TG, FI, and HOMA-IR.
Conclusion : spexin plays an important role in glucose homeostasis and lipid metabolism.
the presence of diabetes is associated with lower spexin levels.
further investigations and additional studies in larger populations are required to understand the exact function of this peptide and to validate the observations in the current study.
American Psychological Association (APA)
Mashal, Yasamin S.& Bakr, Ata M.& al-Bayyumi, Azzah A.& Abbas, Najla E.. 2022. Study of serum spexin level in obese and non-obese type 2 diabetic patient. Suez Canal University Medical Journal،Vol. 25, no. 1, pp.92-99.
https://search.emarefa.net/detail/BIM-1333164
Modern Language Association (MLA)
Mashal, Yasamin S.…[et al.]. Study of serum spexin level in obese and non-obese type 2 diabetic patient. Suez Canal University Medical Journal Vol. 25, no. 1 (2022), pp.92-99.
https://search.emarefa.net/detail/BIM-1333164
American Medical Association (AMA)
Mashal, Yasamin S.& Bakr, Ata M.& al-Bayyumi, Azzah A.& Abbas, Najla E.. Study of serum spexin level in obese and non-obese type 2 diabetic patient. Suez Canal University Medical Journal. 2022. Vol. 25, no. 1, pp.92-99.
https://search.emarefa.net/detail/BIM-1333164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 98-99
Record ID
BIM-1333164