Ameliorative effect of trehalose on liver due to doxorubicin-induced cardiomyopathy in mice
Joint Authors
Abu Khudayr, Rasha H.
Ibrahim, Wafa M.
Salamah, Afrah F.
Shams, Muhammad E.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 63, Issue 1 (31 Oct. 2019), pp.42-50, 9 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2019-10-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Doxorubicin (DOX) is one of the most efficient anticancer chemotherapeutic drugs.
however, its use is limited due to the induction of irreversible dilated cardiomyopathy and hepatotoxicity.
the present study aimed to evaluate the hepatoprotective effect of trehalose (TRE) against DOX –induced cardiomyopathy (DIC).
Mice were divided into five treated groups : control group given saline, DOX group (2mg/kg body weight three times per week for three weeks day after day), TRE group (200μg/mouse three times per week for three weeks day after day), DOX+TRE co-treatment group (animals were co-administered 2mg/kg body weight of DOX with 200μg/mouse TRE by the same time), and DOX+TRE post treatment group (animals received 2mg/kg body weight DOX followed by treatment with 200μg/mouse TRE after 18 days).
the obtained results indicated that DOX-treatment resulted in a decrease in body and liver weight, and relative weight of liver compared to the control group.
In addition, DOX-treatment caused an increase in activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and in level of hepatic malondialdehyde (MDA) concentration.
however, concentration of total thiols (T-thiol), total antioxidant capacity (TAC) as well as catalase (CAT) enzyme activity were reduced in DOX-treated mice.
furthermore, dramatic changes in the histological architecture of the liver were observed.
on the other hand, an improvement in the activities of ALT, AST, and CAT as well as levels of hepatic MDA, T-thiol and TAC were observed in animals administrated with TRE either alone or in combination with DOX in co-treatment and post treatment groups in comparison with the ones treated with DOX alone.
moreover, histopathological examination of liver tissues in mice co-treated with DOX and TRE showed a significant improvement in hepatic parenchyma as compared to mice treated with DOX alone.
American Psychological Association (APA)
Abu Khudayr, Rasha H.& Salamah, Afrah F.& Ibrahim, Wafa M.& Shams, Muhammad E.. 2019. Ameliorative effect of trehalose on liver due to doxorubicin-induced cardiomyopathy in mice. Alexandria Journal of Veterinary Sciences،Vol. 63, no. 1, pp.42-50.
https://search.emarefa.net/detail/BIM-1333535
Modern Language Association (MLA)
Abu Khudayr, Rasha H.…[et al.]. Ameliorative effect of trehalose on liver due to doxorubicin-induced cardiomyopathy in mice. Alexandria Journal of Veterinary Sciences Vol. 63, no. 1 (Oct. 2019), pp.42-50.
https://search.emarefa.net/detail/BIM-1333535
American Medical Association (AMA)
Abu Khudayr, Rasha H.& Salamah, Afrah F.& Ibrahim, Wafa M.& Shams, Muhammad E.. Ameliorative effect of trehalose on liver due to doxorubicin-induced cardiomyopathy in mice. Alexandria Journal of Veterinary Sciences. 2019. Vol. 63, no. 1, pp.42-50.
https://search.emarefa.net/detail/BIM-1333535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 48-50
Record ID
BIM-1333535