Potential protective effect of curcumin on paracetamol model of liver injury in rats
Joint Authors
Taha, Nabil M.
Lubadah, Muhammad A.
Hashim, Amal E.
Sidqi, Raniya A.
Mandour, Abd al-Wahhab A.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 63, Issue 1 (31 Oct. 2019), pp.77-84, 8 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2019-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of the this study is to investigate the protective effect of curcumin on paracetamol induced hepatotoxicity in rats through determination of, serum protein concentration, ammonia, bilirubin, liver enzymes activities, liver lipid peroxidation and antioxidants.
the study was carried on 70 male rats weighing 140± 10 divided into equal 7 groups as following: GI: control, GII: control corn, GIII: curcumin (200mg/kgb.wt/gavage), GIV: curcumin (400mg/kgb.wt/gavage), GV : paracetamol (500mg/kgb.wt/gavage), GVI: Curcumin (200mg/kgb.wt/gavage) + paracetamol (500mg/kgb.wt/gavage) and GVII: curcumin (400mg/kgb.wt/ gavage) + paracetamol (500mg/kgb.wt/ gavage).
after 30 days, blood was collected for biochemical examination.
Paracetamol at dose (500 mg/kg b.wt) caused marked liver damage as there was pronounced increase in bilirubin, ammonia and MDA levels along with marked elevation in liver enzyme activities while levels of serum proteins, GSH and Catalase activity markedly decreased.
interestingly, curcumin was able to ameliorate hepatic deterioration caused by paracetamol via restoring depleted glutathione, rebalanced antioxidants and improved damage as curcumin (200 mg/ kg b.wt) successfully decreased degree of hepatic vacuolation with best improvent via curcumin (400 mg/ kg b.wt).
curcumin showed protective effect on paracetamol induced hepatotoxicity as it successfully improved the altered hepatic parameters and through its powerful antioxidant properties.
American Psychological Association (APA)
Sidqi, Raniya A.& Taha, Nabil M.& Mandour, Abd al-Wahhab A.& Lubadah, Muhammad A.& Hashim, Amal E.. 2019. Potential protective effect of curcumin on paracetamol model of liver injury in rats. Alexandria Journal of Veterinary Sciences،Vol. 63, no. 1, pp.77-84.
https://search.emarefa.net/detail/BIM-1334024
Modern Language Association (MLA)
Sidqi, Raniya A.…[et al.]. Potential protective effect of curcumin on paracetamol model of liver injury in rats. Alexandria Journal of Veterinary Sciences Vol. 63, no. 1 (Oct. 2019), pp.77-84.
https://search.emarefa.net/detail/BIM-1334024
American Medical Association (AMA)
Sidqi, Raniya A.& Taha, Nabil M.& Mandour, Abd al-Wahhab A.& Lubadah, Muhammad A.& Hashim, Amal E.. Potential protective effect of curcumin on paracetamol model of liver injury in rats. Alexandria Journal of Veterinary Sciences. 2019. Vol. 63, no. 1, pp.77-84.
https://search.emarefa.net/detail/BIM-1334024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 82-84
Record ID
BIM-1334024