Effect of introducing the Jordanian common rue (Ruta chalepensis L.)‎ on blood lipid profile in adult male sprague dawley rats toxified with paracetamol

Abstract EN

This study aimed to determine the effect of Ruta chalepensis L.

on blood lipid profile of rats.

An animal experiment was conducted using five groups of Sprague Dawley rats, 9 rats in each group.

The groups were fed: Normal diet, high cholesterol diet (HCD), HCD with or without the plant and with or without paracetamol.

The experiment lasted six weeks; at the end of the sixth week; a single dose of 3g paracetamol /kg body weight was given to two groups, then blood samples were collected to evaluate blood lipid profile.

There were no significant differences among groups in initial weight, final weight, weight gain, and feed efficiency ratio (FER).

Furthermore, HCD significantly increased the accumulative feed intake, whereas the paracetamol (PCM) toxin dose significantly lowered the accumulative feed intake.

The addition of the plant to the diet of rats on HCD significantly lowered the risk of hyperlipidemia, by increasing high-density lipoprotein (HDL) and lowering the triglycerides blood levels (P<0.05).

However, the addition of the plant to the diet did not significantly affect HDL levels in rats toxified with paracetamol.

It can be concluded that the addition of Ruta chalepensis L.

plant to hypercholesterolemic rats would increase their HDL and lower their Triglyceride serum levels.

Besides, the plant can beneficially affect the lipid profile in paracetamol-toxified rats.