Ultrastructural changes of kidney induced by copper nanoparticles and the therapeutic role of vitamins E and C against cytotoxicity

Abstract EN

The ability of nanoparticles as anti-bacterial materials has led to their widespread application in many health products.

however, there are many concerns about the exposure of individuals to these particles, addressed the cellular effects caused by copper nanoparticles on the kidneys using transmission electron microscopy, and investigating the potential therapeutic role of vitamin E and C against the toxicity of copper nanoparticles and their cellular harmful effects.

the study used 56 rats (Rattus norvegicus) divided into seven groups and dosed over a month with copper nanoparticles and then dosed for another month with both vitamins E and C, either alone or together, the results showed that the animals of the groups that were treated with copper nanoparticles showed microstructural changes in the kidneys.

changes were found in the renal tissue at the level of the podocytes forming the endothelial cells in the visceral layer of the renal glomeruli.

it was also observed that mitochondria were affected in the epithelial cells of the Proximal convoluted tubules.

in addition to an increase in the number of lysosomes and cytoplasmic vacuoles.

the effective therapeutic role of vitamin C, E has been shown in improving the size and number of organelles and returning them to their almost normal state.

the study recommends the need to use vitamins C and E at a dose of 250 MG / KG / day, which showed a positive role in reducing the toxicity of copper nanoparticles.