Study the potential effect of (fenugreek and flaxseed)‎ seeds on acute renal failure in rats

Abstract EN

Acute kidney injury is increasingly common around the world ; so the present study was carried out to investigate the potential effect of fenugreek and flaxseed seeds on acute renal failure in rats.

thirty-six male albino rats weighing 140 ± 10 g were used in this study and divided into two main groups, the first main group ( 6 rats ) kept as a negative control group (V -) received a basal diet throughout the experiment period (four weeks), while the second main group (30 rats) were injected by glycerol to induce acute renal failure and divided into five subgroups, the first was the (V +) control group, the second and third given a basal diet supplemented with fenugreek (5%) and (10%),respectively.

the four and five groups were given a basal diet supplemented with flaxseed (5%) and (10%), respectively for four weeks.

the chemical composition, total phenolic and total flavonoids contents for both plants were done.

at the end of the experiment, biological data were calculated ; blood samples were taken to biochemical analysis.

in addition, a histopathological examination for the kidney was done.

the results revealed that body weight gain%, feed intake ,feed efficiency ratio, serum superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) decreased in the (V +) control group.

kidney function ; uric acid, urea, and creatinine , are increased in the (V +) control group.

all treated groups with two plants showed improvement in previous parameters compared with the positive control group, especially treated groups with high doses of plants.

in conclusion, the consumption of fenugreek and flaxseed (5 and 10%) could be used for improving kidney function and protecting from the risk factor of acute renal failure rats.