The effect of some natural herbs on rats suffering from diabetes

Abstract EN

The present study was carried out to evaluate the effect of different ratios of Moringa oleifera (MO), Gymnema sylvestre (GS) leaves, and their combination on diabetic rats.

Male rats (40 rats) were used in this study.

The rats were divided into two groups.

The first group (5 rats) was fed on a basal diet as a control negative group (c-).

While the second main group was diabetic by injection of alloxan (120 mg/kg b.

wt) then divided into seven equal subgroups.

One of them fed on a basal diet as a control positive group (c+), and the other groups fed on a basal diet containing 2.5% & 5% from MO leaves, 2.5% & 5% from GS leaves, and their equal combination by the same ratio.

Fino bread was prepared with the same levels from MO and GS, and their combination.

The results showed that injected rats of alloxan -induced defectiveness in all parameters.

Feeding rats that suffered from diabetes with diets containing the two levels from MO and GS leaves and their combination led to a decrease in serum glucose, triglycerides, total cholesterol, low and very low density lipoprotein cholesterol, uric acid, urea nitrogen, creatinine, and liver enzymes activity (AST, ALT and ALP).

While HDL-c increased, as compared to the positive control.

The results of the sensory evaluation showed an acceptable fino bread prepared in most proportions of the study.

Therefore, the study recommends the use of Moringa oleifera leaves, Gymnema sylvestre, and their combination in preparing fino bread suitable for a diabetic.