Biochemical effects of treatments with herbicide atrazine in male albino rats

Abstract EN

Environmental persistence and bioaccumulation of atrazine which belong to the Chloro -S-triazines may constitute a substantial concern in terms of health of humans.

This research looked at, male albino rats with 195±5 g weights, were orally given doses of 0, 60, 150, and 300 mg a.

i.

/kg b.

w.

atrazine, respectively, daily for 30 days.

Analysis of liver, kidney functions, endocrine disorders, sperm account, sperm motility and body organs weights (olute& relative) were evaluated.

Through the study duration, rats were observed for general behavior, symptoms of toxicity and mortality.

At the end of the study, rats were sacrificed by decapitation after 24 hr.

, from last treatment.

Organs of tested male rats were rapidly doffed washed and weighted individually.

Then, the organ / body weight ratios were calculated, and blood was collected from rats 24 hr.

, after the end of 30 days and subjected for the biochemical parameters.

Atrazine with the tested doses served no apparent signs of toxicity or mortality of treated rats throughout the period of investigation (30 days).

The findings revealed that oral administration of male albino rats with the tested doses of atrazine lowered body weight gains and sperm dynamics, while raised organs weights (except testes weight which was lowered, and did not affect olute kidney weight), the levels of selected liver (except total protein and glucose contents which were decreased) and kidney biomarkers in treated rats compared to control animals.

Concentrations of T₃ were increased significantly in a dose-dependent manner; concentrations of T₄ hormone were increased only with the highest tested dose in treated rats compared to control animals.

In other terms, atrazine is toxic to the body, blood, liver and kidney functions of exposed rats, also as an endocrine disruptor chemical that longtime exposure of atrazine has been shown to have negative consequences on health of humans and the environment.