Synthesis of some new benzoxazepine compounds form derivatives of Schiff bases

Abstract EN

This study involved synthesize (1, 3) oxazepine.

The step 1 includes the preparation of compound (1), (5-Bromo-2-mercapto-6-(4-methoxyphenyl) pyrimidin-4(3H)-one), by the condensation of anisaldehyde and ethylbromoacetat and thiourea in EtOH.

In the step2, chalcones (2-6) have been produced.

The reaction of compound (1) with chalcones (2-6) that gives azo Michael adduct (7-11) is made in the third step.

Schiff's bases (12-16) were prepared by the reaction ketones (7-11) with 2, 4-dinitroaniline.

Finally preparation of new benzo [1, 3] oxazepine compounds (17-21) are prepared by the reaction of phthalic anhydride with Schiff's bases.

The synthesized compounds are identified by physical (melting points, colour change) and spectral methods such as (IR, proton-nmr).