Synthesis characterization and antibacterial activities of some new pyridazines and thieno[2,3-c]pyridazines
Joint Authors
al-Husami, Muhammad H. M.
al-Kamali, Ahmed S. N.
Source
University of Taiz Research Journal : Arts Applied Sciences and Humanities Series
Issue
Vol. 2020, Issue 23 (30 Jun. 2020), pp.1-13, 13 p.
Publisher
Publication Date
2020-06-30
Country of Publication
Yemen
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Novel ethyl 6-phenyltetrazolo[1,5-b]pyridazine-8-carboxylate 4 was synthesized from the reaction of 2-chloro-4-carbethoxy-6-phenylpyridazine 2 with sodium azide in DMF.
Hydrazinolysis of compound 4 yielded the corresponding carbohydrazide, 5.
The reaction of 4-cyano-6-phenylpyridazine-3(2H)-thione 8 with bromoacetone and ethyl chloroacetate in the presence of sodium acetate afforded the novel thieno[2,3-c]pyridazine derivatives 9a,b.
The reaction of amino group in compounds 9a,b with 2,5-dimethoxytetrahydrofuran in acetic acid afforded the corresponding pyrrolyl derivatives 10a, b.
Similarly, treatment of compound 9b with succinc anhydride under reflux in acetic acid yielded the novel 3-(2,5-Dioxopyrrolidin-1-yl)- thienopyridazine 13.
Hydrazinolysis of compounds 10b and 13 produced the novel carbohydrazides, 11 and 19, respectively.
Structure of the new obtained compounds were established by elemental analyses and spectral data.
The new compounds were also screened for their antibacterial activity.
American Psychological Association (APA)
al-Husami, Muhammad H. M.& al-Kamali, Ahmed S. N.. 2020. Synthesis characterization and antibacterial activities of some new pyridazines and thieno[2,3-c]pyridazines. University of Taiz Research Journal : Arts Applied Sciences and Humanities Series،Vol. 2020, no. 23, pp.1-13.
https://search.emarefa.net/detail/BIM-1337506
Modern Language Association (MLA)
al-Husami, Muhammad H. M.& al-Kamali, Ahmed S. N.. Synthesis characterization and antibacterial activities of some new pyridazines and thieno[2,3-c]pyridazines. University of Taiz Research Journal : Arts Applied Sciences and Humanities Series No. 23 (Jun. 2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1337506
American Medical Association (AMA)
al-Husami, Muhammad H. M.& al-Kamali, Ahmed S. N.. Synthesis characterization and antibacterial activities of some new pyridazines and thieno[2,3-c]pyridazines. University of Taiz Research Journal : Arts Applied Sciences and Humanities Series. 2020. Vol. 2020, no. 23, pp.1-13.
https://search.emarefa.net/detail/BIM-1337506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-13
Record ID
BIM-1337506