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Camel milk exosomes had a selective anticancer effect on PANC1 cells and a proliferative effect on H6c7 cells
Joint Authors
Salamah, Muhammad F.
Ali, Mayadah A.
al-Sayyid, Jihad R.
al-Majd, Muhammad A.
Source
Kafr El-Sheikh Veterinary Medical Journal
Issue
Vol. 20, Issue 1 (30 Apr. 2022), pp.1-5, 5 p.
Publisher
Kafr El-Sheikh University Faculty of Veterinary Medicine
Publication Date
2022-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background / aim : in the Middle East, there is a common belief that the daily intake of camel milk prevents cancer and diabetes.
however, the actual anti-cancer and anti-diabetic mechanisms of camel milk remain elusive.
this study aimed to evaluate the effect of camel milk Exosomes on the viability of human pancreatic cancer cells PANC1 and normal pancreatic duct epithelial cells H6c7.
methods : Exosomes were isolated from freshly collected camel milk by gradient ultracentrifugation and were characterized by transmission electron microscope (TEM) and further confirmed by western blot.
cell viability was assessed by MTT assay and relative expression of the pro-apoptotic genes (Bax and caspase3) and the anti-apoptotic gene (Bcl2) were determined by real-time PCR.
results : interestingly, camel milk Exosomes had a selective effect on the cell viability depending on the type of the target cell.
these Exosomes induced a potent cytotoxic effect on the cancer cells (PANC1), while they improved the viability of the normal pancreatic cells (H6c7).
these incredible results were confirmed on a molecular basis.
camel milk Exosomes induced a significant increase in Bax and caspase3 and a significant decrease in Bcl2 mRNA levels in PANC1 cells.
however, the effect on these markers was reversed when Exosomes were added to H6c7 cells.
conclusion : to the best of our knowledge, this may be the first study to report that Exosomes derived from camel milk had a selective anticancer effect on pancreatic cancer cells and a proliferative effect on normal pancreatic cells.
American Psychological Association (APA)
Ali, Mayadah A.& al-Sayyid, Jihad R.& Salamah, Muhammad F.& al-Majd, Muhammad A.. 2022. Camel milk exosomes had a selective anticancer effect on PANC1 cells and a proliferative effect on H6c7 cells. Kafr El-Sheikh Veterinary Medical Journal،Vol. 20, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-1337934
Modern Language Association (MLA)
Ali, Mayadah A.…[et al.]. Camel milk exosomes had a selective anticancer effect on PANC1 cells and a proliferative effect on H6c7 cells. Kafr El-Sheikh Veterinary Medical Journal Vol. 20, no. 1 (2022), pp.1-5.
https://search.emarefa.net/detail/BIM-1337934
American Medical Association (AMA)
Ali, Mayadah A.& al-Sayyid, Jihad R.& Salamah, Muhammad F.& al-Majd, Muhammad A.. Camel milk exosomes had a selective anticancer effect on PANC1 cells and a proliferative effect on H6c7 cells. Kafr El-Sheikh Veterinary Medical Journal. 2022. Vol. 20, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-1337934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-1337934