Effect of phytosomes of different phytoextracts of Trigonella foenum-graecum (Fenugreek seeds)‎, curcuma longa (Turmeric)‎, and Aloe vera (Aloe)‎ on the induced diabetic rats

Other Title(s)

الفيتوسوم يقوي التأثيرات المضادة لفرط شحميات الدم و المضادة لارتفاع السكر في الدم للكركمين في الجرذان المصابة بمرض السكري التي يسببها الستريتوزوتوسين

Dissertant

al-Habshinah, Wasil Salah Ahmad

Thesis advisor

Khulayfat, Khalid Muhammad Awad

University

Mutah University

Faculty

Faculty of Science

Department

Department of Biological Sciences

University Country

Jordan

Degree

Master

Degree Date

2021

English Abstract

Diabetes mellitus (DM) is considered one of the most challenging health problems word wide.

DM is described as a metabolic disorder associated with chronic high blood sugar and disorders of carbohydrate, fat and protein metabolism.

This chronic disease is dealt with through simple intensive normalization of blood sugar, but without preventing disease complications.

Curcumin, which is a phytochemical polyphenol found in turmeric, has been used in the spice and has some hypoglycemic and anti-hyperlipidemic effects.

However, it is difficult to evaluate the effectiveness of natural products such as curcumin on diabetes and its complications, due to the low intestinal bioavailability and the low systemic absorption rate.

Therefore, the efficacy of the phytosome was evaluated in its ability to enhance the absorption of curcumin and thus its effects on blood sugar and lipid profile in streptozotocin (STZ)-nicotinamide induced DM rats.

Curcumin and curcumin-P compound were administered at 150 and 250 mg / kg orally to rats with diabetes.

Blood glucose and lipid profile were monitored for 21 days, which resulted in a significant reduction in blood glucose, cholesterol, triglyceride and low-density lipoprotein (LDL) cholesterol levels, and a significant increase in high-density lipoprotein (HDL) cholesterol levels in the blood.

The results showed that the hyperglycemic and antihyperlipidemic effects caused by treatment with curcumin-P are higher than those treated with curcumin alone at the same dose, indicating that the phytosome enhances the potential of absorption and bioavailability of curcumin.

Main Subjects

Biology

No. of Pages

51

Table of Contents

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Theoretical dackground (Diabetes Profile).

Chapter Two : Literature review.

Chapter Three : Methodology (Materials and Methods).

Chapter Four : Results and discussion.

References.

American Psychological Association (APA)

al-Habshinah, Wasil Salah Ahmad. (2021). Effect of phytosomes of different phytoextracts of Trigonella foenum-graecum (Fenugreek seeds), curcuma longa (Turmeric), and Aloe vera (Aloe) on the induced diabetic rats. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-1338570

Modern Language Association (MLA)

al-Habshinah, Wasil Salah Ahmad. Effect of phytosomes of different phytoextracts of Trigonella foenum-graecum (Fenugreek seeds), curcuma longa (Turmeric), and Aloe vera (Aloe) on the induced diabetic rats. (Master's theses Theses and Dissertations Master). Mutah University. (2021).
https://search.emarefa.net/detail/BIM-1338570

American Medical Association (AMA)

al-Habshinah, Wasil Salah Ahmad. (2021). Effect of phytosomes of different phytoextracts of Trigonella foenum-graecum (Fenugreek seeds), curcuma longa (Turmeric), and Aloe vera (Aloe) on the induced diabetic rats. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-1338570

Language

English

Data Type

Arab Theses

Record ID

BIM-1338570