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Investigation of the molecular mechanisms leading to protein translation inhibition in response to endoplasmic reticulum stress
Other Title(s)
اختبار الآليات الجزيئية المسببة في تثبيط عمليات ترجمة البروتين في حالة إجهاد الشبكة الإندوبلازمية داخل الخلية
Joint Authors
al-Fuways, Abd al-Salam
Herbert, Terence P.
Source
Al-Mukhtar Journal of Sciences
Issue
Vol. 33, Issue 3 (30 Sep. 2018), pp.169-181, 13 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Libya
No. of Pages
13
Main Subjects
Abstract EN
Protein folding is an important process for cellular function.
ER is responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins.
The intracellular disturbance caused by different stressors leading to the accumulation of unfolded/ misfolded proteins can all lead to an alteration in ER homeostasis.
If the unfolded/misfolded proteins continue to accumulate inside the ER, the unfolded protein response (UPR) is induced to overcome this situation.
UPR acts by three different mechanisms:(1) increase the ER protein-folding capacity (Robertsonand Branch, 1987),(2) reduce global protein synthesis, and (3) enhance ER-associated degradation process.
The UPR is mediated by three ER transmembrane protein sensors: (1) activating transcription factor 6 (ATF6), (2) inositol requiring kinase 1(IRE1), and (3) double-stranded RNA-activated protein kinase (PKR) like endoplasmic reticulum kinase (PERK).
Each sensor of the UPR protein responds to the certain level of unfolded/misfolded protein in the ER.
If the cell fails to restore or overcome the protein-folding defect, cell-death signaling pathways are activated.
American Psychological Association (APA)
al-Fuways, Abd al-Salam& Herbert, Terence P.. 2018. Investigation of the molecular mechanisms leading to protein translation inhibition in response to endoplasmic reticulum stress. Al-Mukhtar Journal of Sciences،Vol. 33, no. 3, pp.169-181.
https://search.emarefa.net/detail/BIM-1340390
Modern Language Association (MLA)
al-Fuways, Abd al-Salam& Herbert, Terence P.. Investigation of the molecular mechanisms leading to protein translation inhibition in response to endoplasmic reticulum stress. Al-Mukhtar Journal of Sciences Vol. 33, no. 3 (2018), pp.169-181.
https://search.emarefa.net/detail/BIM-1340390
American Medical Association (AMA)
al-Fuways, Abd al-Salam& Herbert, Terence P.. Investigation of the molecular mechanisms leading to protein translation inhibition in response to endoplasmic reticulum stress. Al-Mukhtar Journal of Sciences. 2018. Vol. 33, no. 3, pp.169-181.
https://search.emarefa.net/detail/BIM-1340390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 176-180
Record ID
BIM-1340390