A review on clinical, pathological characteristics and drug designing for COVID-19

Joint Authors

Mukhtar, Hamid
Ashraf, Muhammad Usamah
Sharif, Sundus
Ahmad, Muhammad Uthman
Zahid, Muhammad Numan

Source

Arab Journal of Basic and Applied Sciences

Issue

Vol. 28, Issue 1 (31 Dec. 2021), pp.172-186, 15 p.

Publisher

University of Bahrain College of Science

Publication Date

2021-12-31

Country of Publication

Bahrain

No. of Pages

15

Main Subjects

Biology

Abstract EN

In late 2019, a novel strain of coronavirus (2019-nCoV) named as severe respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, a city in China, through some zoonotic reservoir, most probably a bat, and spread throughout the world.

There have been around 22,213,869 reported cases of COVID-19 and almost 781,677 deaths worldwide according to the data updated by World Health Organization till 20 August 2020.

It transmitted via droplets from an infected person to a healthy person in a very short duration of time.

After the completion of the incubation period, which ranges from 2 to 14 days, the person experiences pneumonia-like symptoms such as fever, sore throat, cough, breathlessness, malaise, fatigue, and multi-organ dysfunction, etc.

The main receptor of SARS-CoV-2 is angiotensin-converting enzyme 2 which binds with the spike (S) protein of the virus and helps it in attachment and entry to the host cells.

COVID-19 is diagnosed by molecular testing of respiratory secretions and CT scan analysis.

Because of the absence of any approved treatment options for COVID-19, a number of research studies are being carried out to find out any combination of already approved drugs or new lead compounds using in silico docking and screening strategies.

American Psychological Association (APA)

Ashraf, Muhammad Usamah& Sharif, Sundus& Ahmad, Muhammad Uthman& Zahid, Muhammad Numan& Mukhtar, Hamid. 2021. A review on clinical, pathological characteristics and drug designing for COVID-19. Arab Journal of Basic and Applied Sciences،Vol. 28, no. 1, pp.172-186.
https://search.emarefa.net/detail/BIM-1340622

Modern Language Association (MLA)

Mukhtar, Hamid…[et al.]. A review on clinical, pathological characteristics and drug designing for COVID-19. Arab Journal of Basic and Applied Sciences Vol. 28, no. 1 (2021), pp.172-186.
https://search.emarefa.net/detail/BIM-1340622

American Medical Association (AMA)

Ashraf, Muhammad Usamah& Sharif, Sundus& Ahmad, Muhammad Uthman& Zahid, Muhammad Numan& Mukhtar, Hamid. A review on clinical, pathological characteristics and drug designing for COVID-19. Arab Journal of Basic and Applied Sciences. 2021. Vol. 28, no. 1, pp.172-186.
https://search.emarefa.net/detail/BIM-1340622

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 183-186

Record ID

BIM-1340622